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Sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients

To estimate the association between central retinal artery occlusion (CRAO) and major adverse cardiovascular and cerebrovascular events (MACCE), including their clinical characteristics, blood markers, and the contribution of CRAO to MACCE, as well as to assess any sex differences. This retrospectiv...

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Autores principales: Chen, Ting, Wang, Yuedan, Li, Xuejie, Feng, Jiaqing, Yang, Hongxia, Li, Ying, Feng, Hui, Xiao, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495358/
https://www.ncbi.nlm.nih.gov/pubmed/37696870
http://dx.doi.org/10.1038/s41598-023-42247-2
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author Chen, Ting
Wang, Yuedan
Li, Xuejie
Feng, Jiaqing
Yang, Hongxia
Li, Ying
Feng, Hui
Xiao, Xuan
author_facet Chen, Ting
Wang, Yuedan
Li, Xuejie
Feng, Jiaqing
Yang, Hongxia
Li, Ying
Feng, Hui
Xiao, Xuan
author_sort Chen, Ting
collection PubMed
description To estimate the association between central retinal artery occlusion (CRAO) and major adverse cardiovascular and cerebrovascular events (MACCE), including their clinical characteristics, blood markers, and the contribution of CRAO to MACCE, as well as to assess any sex differences. This retrospective cohort study included continuous new-onset CRAO patients and 1:4 controls during the same period. Correlations of CRAO with the incidence of MACCE during follow-up and the sex-related differences were studied. One hundred and twenty-four CRAO patients and four hundred and ninety-six controls were enrolled. Neutrophil-to-lymphocyte ratio (NLR, P = 0.014) and high-sensitivity C-reactive protein (hs-CRP, P = 0.038) were tended to be higher in CRAO patients. After the follow-up period, 78 patients experienced MACCE. Multivariate Cox regression analysis showed that CRAO was a predictor of the occurrence of MACCE (HR 2.321, 95% CI 1.439–3.744, P = 0.001). Sex subgroups indicated that age, diabetes, current smoking, CRAO, NLR and hs-CRP increased the risk factor of MACCE in males (All P < 0.05) and CRAO, NLR, low-density lipoprotein cholesterol (LDL-C) and hs-CRP were independent influencing factors for females (All P < 0.05). New-onset CRAO significantly increases the probability of MACCE and is associated with a poor prognosis. The sex-related differences suggested that effective prevention of the occurrence of MACCE in high-risk patients requires that attention be given to individualized risk factors corresponding to sexes.
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spelling pubmed-104953582023-09-13 Sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients Chen, Ting Wang, Yuedan Li, Xuejie Feng, Jiaqing Yang, Hongxia Li, Ying Feng, Hui Xiao, Xuan Sci Rep Article To estimate the association between central retinal artery occlusion (CRAO) and major adverse cardiovascular and cerebrovascular events (MACCE), including their clinical characteristics, blood markers, and the contribution of CRAO to MACCE, as well as to assess any sex differences. This retrospective cohort study included continuous new-onset CRAO patients and 1:4 controls during the same period. Correlations of CRAO with the incidence of MACCE during follow-up and the sex-related differences were studied. One hundred and twenty-four CRAO patients and four hundred and ninety-six controls were enrolled. Neutrophil-to-lymphocyte ratio (NLR, P = 0.014) and high-sensitivity C-reactive protein (hs-CRP, P = 0.038) were tended to be higher in CRAO patients. After the follow-up period, 78 patients experienced MACCE. Multivariate Cox regression analysis showed that CRAO was a predictor of the occurrence of MACCE (HR 2.321, 95% CI 1.439–3.744, P = 0.001). Sex subgroups indicated that age, diabetes, current smoking, CRAO, NLR and hs-CRP increased the risk factor of MACCE in males (All P < 0.05) and CRAO, NLR, low-density lipoprotein cholesterol (LDL-C) and hs-CRP were independent influencing factors for females (All P < 0.05). New-onset CRAO significantly increases the probability of MACCE and is associated with a poor prognosis. The sex-related differences suggested that effective prevention of the occurrence of MACCE in high-risk patients requires that attention be given to individualized risk factors corresponding to sexes. Nature Publishing Group UK 2023-09-11 /pmc/articles/PMC10495358/ /pubmed/37696870 http://dx.doi.org/10.1038/s41598-023-42247-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chen, Ting
Wang, Yuedan
Li, Xuejie
Feng, Jiaqing
Yang, Hongxia
Li, Ying
Feng, Hui
Xiao, Xuan
Sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients
title Sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients
title_full Sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients
title_fullStr Sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients
title_full_unstemmed Sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients
title_short Sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients
title_sort sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495358/
https://www.ncbi.nlm.nih.gov/pubmed/37696870
http://dx.doi.org/10.1038/s41598-023-42247-2
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