Cargando…
Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis
Elevated uric acid (UA) levels have been reported in malaria patients and are particularly prominent in severe malaria cases. This study aims to synthesize the difference in UA levels between malaria patients and uninfected controls, and between patients with severe and non-severe malaria. A compreh...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495360/ https://www.ncbi.nlm.nih.gov/pubmed/37697061 http://dx.doi.org/10.1038/s41598-023-42217-8 |
_version_ | 1785104876988006400 |
---|---|
author | Kuraeiad, Saruda Kotepui, Kwuntida Uthaisar Masangkay, Frederick Ramirez Mahittikorn, Aongart Kotepui, Manas |
author_facet | Kuraeiad, Saruda Kotepui, Kwuntida Uthaisar Masangkay, Frederick Ramirez Mahittikorn, Aongart Kotepui, Manas |
author_sort | Kuraeiad, Saruda |
collection | PubMed |
description | Elevated uric acid (UA) levels have been reported in malaria patients and are particularly prominent in severe malaria cases. This study aims to synthesize the difference in UA levels between malaria patients and uninfected controls, and between patients with severe and non-severe malaria. A comprehensive literature search was carried out across databases such as Embase, MEDLINE, Ovid, PubMed, Scopus, ProQuest, and Google Scholar to identify relevant studies for inclusion. The methodological quality of the included studies was evaluated independently by two reviewers using the JBI critical appraisal tool for observational studies. A meta-analysis was performed to calculate the pooled effect sizes, expressed as Hedges' g, with 95% confidence intervals (CIs). The Hedges' g was pooled using the random-effects model. An initial search yielding a total of 1122 articles, and a final total of 19 studies being included in the review. Elevated UA levels were observed more prominently in malaria patients, especially those with severe manifestations, when compared to uninfected controls. The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from malaria as compared to uninfected controls (P < 0.01, Hedges’s g = 1.40, 95% CI 0.84–1.95, I(2) = 95.81, 16 studies). The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from severe malaria as compared to non-severe malaria (P < 0.01, Hedges’s g = 3.45, 95% CI 1.06–5.83, I(2) = 98.73, 6 studies). In summary, these findings provide valuable insights into the potential use of UA as a biomarker for malaria infection and determination of its severity. Further research is needed to validate these findings and to explore the underlying mechanisms that contribute to the elevation of UA levels during malaria infection. |
format | Online Article Text |
id | pubmed-10495360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104953602023-09-13 Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis Kuraeiad, Saruda Kotepui, Kwuntida Uthaisar Masangkay, Frederick Ramirez Mahittikorn, Aongart Kotepui, Manas Sci Rep Article Elevated uric acid (UA) levels have been reported in malaria patients and are particularly prominent in severe malaria cases. This study aims to synthesize the difference in UA levels between malaria patients and uninfected controls, and between patients with severe and non-severe malaria. A comprehensive literature search was carried out across databases such as Embase, MEDLINE, Ovid, PubMed, Scopus, ProQuest, and Google Scholar to identify relevant studies for inclusion. The methodological quality of the included studies was evaluated independently by two reviewers using the JBI critical appraisal tool for observational studies. A meta-analysis was performed to calculate the pooled effect sizes, expressed as Hedges' g, with 95% confidence intervals (CIs). The Hedges' g was pooled using the random-effects model. An initial search yielding a total of 1122 articles, and a final total of 19 studies being included in the review. Elevated UA levels were observed more prominently in malaria patients, especially those with severe manifestations, when compared to uninfected controls. The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from malaria as compared to uninfected controls (P < 0.01, Hedges’s g = 1.40, 95% CI 0.84–1.95, I(2) = 95.81, 16 studies). The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from severe malaria as compared to non-severe malaria (P < 0.01, Hedges’s g = 3.45, 95% CI 1.06–5.83, I(2) = 98.73, 6 studies). In summary, these findings provide valuable insights into the potential use of UA as a biomarker for malaria infection and determination of its severity. Further research is needed to validate these findings and to explore the underlying mechanisms that contribute to the elevation of UA levels during malaria infection. Nature Publishing Group UK 2023-09-11 /pmc/articles/PMC10495360/ /pubmed/37697061 http://dx.doi.org/10.1038/s41598-023-42217-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kuraeiad, Saruda Kotepui, Kwuntida Uthaisar Masangkay, Frederick Ramirez Mahittikorn, Aongart Kotepui, Manas Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
title | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
title_full | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
title_fullStr | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
title_full_unstemmed | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
title_short | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
title_sort | association of uric acid levels with severity of plasmodium infections: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495360/ https://www.ncbi.nlm.nih.gov/pubmed/37697061 http://dx.doi.org/10.1038/s41598-023-42217-8 |
work_keys_str_mv | AT kuraeiadsaruda associationofuricacidlevelswithseverityofplasmodiuminfectionsasystematicreviewandmetaanalysis AT kotepuikwuntidauthaisar associationofuricacidlevelswithseverityofplasmodiuminfectionsasystematicreviewandmetaanalysis AT masangkayfrederickramirez associationofuricacidlevelswithseverityofplasmodiuminfectionsasystematicreviewandmetaanalysis AT mahittikornaongart associationofuricacidlevelswithseverityofplasmodiuminfectionsasystematicreviewandmetaanalysis AT kotepuimanas associationofuricacidlevelswithseverityofplasmodiuminfectionsasystematicreviewandmetaanalysis |