Cargando…

Umbilical cord mesenchymal stem cells relieve osteoarthritis in rats through immunoregulation and inhibition of chondrocyte apoptosis

This study aims to investigate the effectiveness of umbilical cord mesenchymal stem cells (UCMSCs) in treating osteoarthritis (OA). Sprague–Dawley rats were used in in vivo experiments and divided into four groups: normal, OA model, saline, and UCMSC-treated groups (n = 6). An OA model was establish...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Xin, Li, Xiongfeng, Zhang, Ling, Wu, Feifei, Zhang, Qiang, Xu, Shasha, Shen, Chengchun, Liang, Jinfeng, Pan, Ruolang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495383/ https://www.ncbi.nlm.nih.gov/pubmed/37697034 http://dx.doi.org/10.1038/s41598-023-42349-x

Ejemplares similares

Strategy insight: Mechanical properties of biomaterials’ influence on hydrogel-mesenchymal stromal cell combination for osteoarthritis therapy
por: Ying, Haoli, et al.
Publicado: (2023)

RNA-Sequencing approach for exploring the therapeutic effect of umbilical cord mesenchymal stem/stromal cells on lipopolysaccharide-induced acute lung injury
por: Cui, Enhai, et al.
Publicado: (2022)

Repeat-dose toxicity study of human umbilical cord mesenchymal stem cells in cynomolgus monkeys by intravenous and subcutaneous injection
por: Pan, Wei, et al.
Publicado: (2023)

Umbilical Cord Mesenchymal Stem Cells Ameliorate Premature Ovarian Insufficiency in Rats
por: Zhang, Meiliang, et al.
Publicado: (2022)

Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury
por: Ren, Haitao, et al.
Publicado: (2018)

Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews
por: Yin, Cunping, et al.
Publicado: (2016)

Human umbilical cord mesenchymal stem cells-derived exosomes exert anti-inflammatory effects on osteoarthritis chondrocytes
por: Wang, Shichao, et al.
Publicado: (2023)

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice
por: Mao, Fei, et al.
Publicado: (2017)

Hydroxyapatite-Based Colloidal Gels Facilitate the Proliferation and Migration of Chondrocytes and the Adhesion of Umbilical Cord Mesenchymal Stem Cells
por: Jamal, Syed A., et al.
Publicado: (2014)

Immunoregulation of synovial macrophages for the treatment of osteoarthritis
por: Xu, Mingze, et al.
Publicado: (2023)

MiR-4303 relieves chondrocyte inflammation by targeting ASPN in osteoarthritis
por: Wang, Chunyu, et al.
Publicado: (2021)

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Contribute to Chondrogenesis in Coculture with Chondrocytes
por: Li, Xingfu, et al.
Publicado: (2016)

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
por: Hwang, Hyun Sook, et al.
Publicado: (2015)

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice
por: Lu, XiaoJuan, et al.
Publicado: (2022)

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury
por: Zhao, Yuanyuan, et al.
Publicado: (2015)

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis
por: Musumeci, Giuseppe, et al.
Publicado: (2015)

Cytokine-primed umbilical cord mesenchymal stem cells enhanced therapeutic effects of extracellular vesicles on osteoarthritic chondrocytes
por: Nguyen, Thu Huyen, et al.
Publicado: (2022)

Therapeutic effects of different intervention forms of human umbilical cord mesenchymal stem cells in the treatment of osteoarthritis
por: Zhang, Yuelong, et al.
Publicado: (2023)

Cell-to-Cell Culture Inhibits Dedifferentiation of Chondrocytes and Induces Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells
por: Li, Xingfu, et al.
Publicado: (2019)

BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice
por: Shao, Yan, et al.
Publicado: (2021)

The human umbilical cord stem cells improve the viability of OA degenerated chondrocytes
por: Wang, Hao, et al.
Publicado: (2018)

Progress in the treatment of osteoarthritis with umbilical cord stem cells
por: Liang, Hanguang, et al.
Publicado: (2020)

Articular chondrocyte-derived extracellular vesicles promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy
por: Ma, Ke, et al.
Publicado: (2020)

Exosomes derived from umbilical cord mesenchymal stem cells protect cartilage and regulate the polarization of macrophages in osteoarthritis
por: Li, Pengdong, et al.
Publicado: (2022)

Cost Effectiveness of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Patients with Knee Osteoarthritis
por: Suh, Kangho, et al.
Publicado: (2022)

Umbilical Cord Mesenchymal Stem Cell Secretome Improves Clinical Outcomes and Changes Biomarkers in Knee Osteoarthritis
por: Partan, Radiyati Umi, et al.
Publicado: (2023)

Mtu1 defects are correlated with reduced osteogenic differentiation
por: He, Qiufen, et al.
Publicado: (2021)

Repairing and Analgesic Effects of Umbilical Cord Mesenchymal Stem Cell Transplantation in Mice with Spinal Cord Injury
por: Wu, Ling-ling, et al.
Publicado: (2020)

Human umbilical cord mesenchymal stem cells ameliorate acute liver failure by inhibiting apoptosis, inflammation and pyroptosis
por: Liu, Mengting, et al.
Publicado: (2021)

Comparison of Curative Effect of Human Umbilical Cord-Derived Mesenchymal Stem Cells and Their Small Extracellular Vesicles in Treating Osteoarthritis
por: Tang, Shijie, et al.
Publicado: (2021)

MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and bone marrow mesenchymal stem cell chondrogenesis
por: Feng, Lu, et al.
Publicado: (2022)

Exosomes from Human Umbilical Cord Mesenchymal Stem Cells: Identification, Purification, and Biological Characteristics
por: Zhang, Bin, et al.
Publicado: (2016)

IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis
por: Huang, Rongxiang, et al.
Publicado: (2021)

Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications
por: Castro-Manrreza, Marta E., et al.
Publicado: (2015)

Allogenic Umbilical Cord Tissue as a Scaffold for Ankle Osteoarthritis
por: Gupta, Ashim, et al.
Publicado: (2023)

Human umbilical cord mesenchymal stem cells promoting knee joint chondrogenesis for the treatment of knee osteoarthritis: a systematic review
por: Zhang, Pengwei, et al.
Publicado: (2023)

Transplanting human umbilical cord mesenchymal stem cells and hyaluronate hydrogel repairs cartilage of osteoarthritis in the minipig model
por: Wu, Kun-Chi, et al.
Publicado: (2019)

Correction to: Cost Effectiveness of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Patients with Knee Osteoarthritis
por: Suh, Kangho, et al.
Publicado: (2022)

Identification of the osteoarthritis signature gene PDK1 by machine learning and its regulatory mechanisms on chondrocyte autophagy and apoptosis
por: Meng, Jinzhi, et al.
Publicado: (2023)

Anti-oxidative effect of zinc in human umbilical cord mesenchymal stem cells
por: Lu, Xiaodan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vq9rc0qs5d1n5hea2cv8neohmc