Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome

Downregulation of endothelial Sirtuin1 (Sirt1) in insulin resistant states contributes to vascular dysfunction. Furthermore, Sirt1 deficiency in skeletal myocytes promotes insulin resistance. Here, we show that deletion of endothelial Sirt1, while impairing endothelial function, paradoxically improv...

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Detalles Bibliográficos
Autores principales: Li, Qiuxia, Zhang, Quanjiang, Kim, Young-Rae, Gaddam, Ravinder Reddy, Jacobs, Julia S., Bachschmid, Markus M., Younis, Tsneem, Zhu, Zhiyong, Zingman, Leonid, London, Barry, Rauckhorst, Adam J., Taylor, Eric B., Norris, Andrew W., Vikram, Ajit, Irani, Kaikobad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495425/
https://www.ncbi.nlm.nih.gov/pubmed/37696839
http://dx.doi.org/10.1038/s41467-023-41351-1

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