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The spatial and temporal structure of neural activity across the fly brain
What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous be...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495430/ https://www.ncbi.nlm.nih.gov/pubmed/37696814 http://dx.doi.org/10.1038/s41467-023-41261-2 |
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author | Schaffer, Evan S. Mishra, Neeli Whiteway, Matthew R. Li, Wenze Vancura, Michelle B. Freedman, Jason Patel, Kripa B. Voleti, Venkatakaushik Paninski, Liam Hillman, Elizabeth M. C. Abbott, L. F. Axel, Richard |
author_facet | Schaffer, Evan S. Mishra, Neeli Whiteway, Matthew R. Li, Wenze Vancura, Michelle B. Freedman, Jason Patel, Kripa B. Voleti, Venkatakaushik Paninski, Liam Hillman, Elizabeth M. C. Abbott, L. F. Axel, Richard |
author_sort | Schaffer, Evan S. |
collection | PubMed |
description | What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous behaviors. This revealed neural representations of behavior on multiple spatial and temporal scales. The activity of most neurons correlated (or anticorrelated) with running and flailing over timescales that ranged from seconds to a minute. Grooming elicited a weaker global response. Significant residual activity not directly correlated with behavior was high dimensional and reflected the activity of small clusters of spatially organized neurons that may correspond to genetically defined cell types. These clusters participate in the global dynamics, indicating that neural activity reflects a combination of local and broadly distributed components. This suggests that microcircuits with highly specified functions are provided with knowledge of the larger context in which they operate. |
format | Online Article Text |
id | pubmed-10495430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104954302023-09-13 The spatial and temporal structure of neural activity across the fly brain Schaffer, Evan S. Mishra, Neeli Whiteway, Matthew R. Li, Wenze Vancura, Michelle B. Freedman, Jason Patel, Kripa B. Voleti, Venkatakaushik Paninski, Liam Hillman, Elizabeth M. C. Abbott, L. F. Axel, Richard Nat Commun Article What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous behaviors. This revealed neural representations of behavior on multiple spatial and temporal scales. The activity of most neurons correlated (or anticorrelated) with running and flailing over timescales that ranged from seconds to a minute. Grooming elicited a weaker global response. Significant residual activity not directly correlated with behavior was high dimensional and reflected the activity of small clusters of spatially organized neurons that may correspond to genetically defined cell types. These clusters participate in the global dynamics, indicating that neural activity reflects a combination of local and broadly distributed components. This suggests that microcircuits with highly specified functions are provided with knowledge of the larger context in which they operate. Nature Publishing Group UK 2023-09-11 /pmc/articles/PMC10495430/ /pubmed/37696814 http://dx.doi.org/10.1038/s41467-023-41261-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Schaffer, Evan S. Mishra, Neeli Whiteway, Matthew R. Li, Wenze Vancura, Michelle B. Freedman, Jason Patel, Kripa B. Voleti, Venkatakaushik Paninski, Liam Hillman, Elizabeth M. C. Abbott, L. F. Axel, Richard The spatial and temporal structure of neural activity across the fly brain |
title | The spatial and temporal structure of neural activity across the fly brain |
title_full | The spatial and temporal structure of neural activity across the fly brain |
title_fullStr | The spatial and temporal structure of neural activity across the fly brain |
title_full_unstemmed | The spatial and temporal structure of neural activity across the fly brain |
title_short | The spatial and temporal structure of neural activity across the fly brain |
title_sort | spatial and temporal structure of neural activity across the fly brain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495430/ https://www.ncbi.nlm.nih.gov/pubmed/37696814 http://dx.doi.org/10.1038/s41467-023-41261-2 |
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