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Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin
Patients with diabetes often have difficult-to-heal wounds. Spinacia oleracea extract comprises anti-inflammatory and anti-oxidative compounds; this research, therefore, studied the impact of Spinacia oleracea extracts on ulcer regeneration. This study was conducted on 72 adult Wistar rats (200 [For...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495437/ https://www.ncbi.nlm.nih.gov/pubmed/37696865 http://dx.doi.org/10.1038/s41598-023-42033-0 |
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author | Rahati, Sara Kamalinezhad, Mohammad Ebrahimi, Abdolali Eshraghian, Mohammadreza Pishva, Hamideh |
author_facet | Rahati, Sara Kamalinezhad, Mohammad Ebrahimi, Abdolali Eshraghian, Mohammadreza Pishva, Hamideh |
author_sort | Rahati, Sara |
collection | PubMed |
description | Patients with diabetes often have difficult-to-heal wounds. Spinacia oleracea extract comprises anti-inflammatory and anti-oxidative compounds; this research, therefore, studied the impact of Spinacia oleracea extracts on ulcer regeneration. This study was conducted on 72 adult Wistar rats (200 [Formula: see text] 20 g). They were randomly divided into six groups of twelve. A: Diabetic group receiving normal saline. B: Non-diabetic group receiving normal saline. C: Diabetic group receiving spinach aqueous extract. D: Diabetic group receiving spinach alcoholic extract. E: preventive group that received aqueous extract for 2 months. F: preventive group that received alcoholic extract for 2 months. Ulcer regeneration, vascular endothelium growth factor, blood sugar, and weight changes were measured on days 3, 7, 14, 21, and 30. Macroscopic investigation of the wounds non-diabetic control group, diabetic group, as well as spinach aqueous and alcoholic extract groups, were compared and there were significant changes (P < 0.05). Pathologic examination in the spinach aqueous and alcoholic extract groups, and nondiabetic group than in the diabetic group revealed significant advances (P < 0.05). On the third and seventh days, Vascular endothelium growth factor detected significant differences between groups (P < 0.05). Results indicate that, in regenerating diabetic ulcers, Spinacia oleracea may be effective. It influences the ulcer structure and speed. |
format | Online Article Text |
id | pubmed-10495437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104954372023-09-13 Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin Rahati, Sara Kamalinezhad, Mohammad Ebrahimi, Abdolali Eshraghian, Mohammadreza Pishva, Hamideh Sci Rep Article Patients with diabetes often have difficult-to-heal wounds. Spinacia oleracea extract comprises anti-inflammatory and anti-oxidative compounds; this research, therefore, studied the impact of Spinacia oleracea extracts on ulcer regeneration. This study was conducted on 72 adult Wistar rats (200 [Formula: see text] 20 g). They were randomly divided into six groups of twelve. A: Diabetic group receiving normal saline. B: Non-diabetic group receiving normal saline. C: Diabetic group receiving spinach aqueous extract. D: Diabetic group receiving spinach alcoholic extract. E: preventive group that received aqueous extract for 2 months. F: preventive group that received alcoholic extract for 2 months. Ulcer regeneration, vascular endothelium growth factor, blood sugar, and weight changes were measured on days 3, 7, 14, 21, and 30. Macroscopic investigation of the wounds non-diabetic control group, diabetic group, as well as spinach aqueous and alcoholic extract groups, were compared and there were significant changes (P < 0.05). Pathologic examination in the spinach aqueous and alcoholic extract groups, and nondiabetic group than in the diabetic group revealed significant advances (P < 0.05). On the third and seventh days, Vascular endothelium growth factor detected significant differences between groups (P < 0.05). Results indicate that, in regenerating diabetic ulcers, Spinacia oleracea may be effective. It influences the ulcer structure and speed. Nature Publishing Group UK 2023-09-11 /pmc/articles/PMC10495437/ /pubmed/37696865 http://dx.doi.org/10.1038/s41598-023-42033-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Rahati, Sara Kamalinezhad, Mohammad Ebrahimi, Abdolali Eshraghian, Mohammadreza Pishva, Hamideh Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin |
title | Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin |
title_full | Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin |
title_fullStr | Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin |
title_full_unstemmed | Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin |
title_short | Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin |
title_sort | accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495437/ https://www.ncbi.nlm.nih.gov/pubmed/37696865 http://dx.doi.org/10.1038/s41598-023-42033-0 |
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