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Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin

Patients with diabetes often have difficult-to-heal wounds. Spinacia oleracea extract comprises anti-inflammatory and anti-oxidative compounds; this research, therefore, studied the impact of Spinacia oleracea extracts on ulcer regeneration. This study was conducted on 72 adult Wistar rats (200 [For...

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Autores principales: Rahati, Sara, Kamalinezhad, Mohammad, Ebrahimi, Abdolali, Eshraghian, Mohammadreza, Pishva, Hamideh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495437/
https://www.ncbi.nlm.nih.gov/pubmed/37696865
http://dx.doi.org/10.1038/s41598-023-42033-0
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author Rahati, Sara
Kamalinezhad, Mohammad
Ebrahimi, Abdolali
Eshraghian, Mohammadreza
Pishva, Hamideh
author_facet Rahati, Sara
Kamalinezhad, Mohammad
Ebrahimi, Abdolali
Eshraghian, Mohammadreza
Pishva, Hamideh
author_sort Rahati, Sara
collection PubMed
description Patients with diabetes often have difficult-to-heal wounds. Spinacia oleracea extract comprises anti-inflammatory and anti-oxidative compounds; this research, therefore, studied the impact of Spinacia oleracea extracts on ulcer regeneration. This study was conducted on 72 adult Wistar rats (200 [Formula: see text] 20 g). They were randomly divided into six groups of twelve. A: Diabetic group receiving normal saline. B: Non-diabetic group receiving normal saline. C: Diabetic group receiving spinach aqueous extract. D: Diabetic group receiving spinach alcoholic extract. E: preventive group that received aqueous extract for 2 months. F: preventive group that received alcoholic extract for 2 months. Ulcer regeneration, vascular endothelium growth factor, blood sugar, and weight changes were measured on days 3, 7, 14, 21, and 30. Macroscopic investigation of the wounds non-diabetic control group, diabetic group, as well as spinach aqueous and alcoholic extract groups, were compared and there were significant changes (P < 0.05). Pathologic examination in the spinach aqueous and alcoholic extract groups, and nondiabetic group than in the diabetic group revealed significant advances (P <  0.05). On the third and seventh days, Vascular endothelium growth factor detected significant differences between groups (P < 0.05). Results indicate that, in regenerating diabetic ulcers, Spinacia oleracea may be effective. It influences the ulcer structure and speed.
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spelling pubmed-104954372023-09-13 Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin Rahati, Sara Kamalinezhad, Mohammad Ebrahimi, Abdolali Eshraghian, Mohammadreza Pishva, Hamideh Sci Rep Article Patients with diabetes often have difficult-to-heal wounds. Spinacia oleracea extract comprises anti-inflammatory and anti-oxidative compounds; this research, therefore, studied the impact of Spinacia oleracea extracts on ulcer regeneration. This study was conducted on 72 adult Wistar rats (200 [Formula: see text] 20 g). They were randomly divided into six groups of twelve. A: Diabetic group receiving normal saline. B: Non-diabetic group receiving normal saline. C: Diabetic group receiving spinach aqueous extract. D: Diabetic group receiving spinach alcoholic extract. E: preventive group that received aqueous extract for 2 months. F: preventive group that received alcoholic extract for 2 months. Ulcer regeneration, vascular endothelium growth factor, blood sugar, and weight changes were measured on days 3, 7, 14, 21, and 30. Macroscopic investigation of the wounds non-diabetic control group, diabetic group, as well as spinach aqueous and alcoholic extract groups, were compared and there were significant changes (P < 0.05). Pathologic examination in the spinach aqueous and alcoholic extract groups, and nondiabetic group than in the diabetic group revealed significant advances (P <  0.05). On the third and seventh days, Vascular endothelium growth factor detected significant differences between groups (P < 0.05). Results indicate that, in regenerating diabetic ulcers, Spinacia oleracea may be effective. It influences the ulcer structure and speed. Nature Publishing Group UK 2023-09-11 /pmc/articles/PMC10495437/ /pubmed/37696865 http://dx.doi.org/10.1038/s41598-023-42033-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rahati, Sara
Kamalinezhad, Mohammad
Ebrahimi, Abdolali
Eshraghian, Mohammadreza
Pishva, Hamideh
Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin
title Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin
title_full Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin
title_fullStr Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin
title_full_unstemmed Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin
title_short Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin
title_sort accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495437/
https://www.ncbi.nlm.nih.gov/pubmed/37696865
http://dx.doi.org/10.1038/s41598-023-42033-0
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