Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania

RNA viruses play an important role in Leishmania biology and virulence. Their presence was documented in three (out of four) Leishmania subgenera. Sauroleishmania of reptiles remained the only underinvestigated group. In this work, we analyzed the viral occurrence in Sauroleishmania spp. and detecte...

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Autores principales: Klocek, Donnamae, Grybchuk, Danyil, Tichá, Lucie, Votýpka, Jan, Volf, Petr, Kostygov, Alexei Yu., Yurchenko, Vyacheslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495512/
https://www.ncbi.nlm.nih.gov/pubmed/37490143
http://dx.doi.org/10.1007/s00436-023-07928-x
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author Klocek, Donnamae
Grybchuk, Danyil
Tichá, Lucie
Votýpka, Jan
Volf, Petr
Kostygov, Alexei Yu.
Yurchenko, Vyacheslav
author_facet Klocek, Donnamae
Grybchuk, Danyil
Tichá, Lucie
Votýpka, Jan
Volf, Petr
Kostygov, Alexei Yu.
Yurchenko, Vyacheslav
author_sort Klocek, Donnamae
collection PubMed
description RNA viruses play an important role in Leishmania biology and virulence. Their presence was documented in three (out of four) Leishmania subgenera. Sauroleishmania of reptiles remained the only underinvestigated group. In this work, we analyzed the viral occurrence in Sauroleishmania spp. and detected RNA viruses in three out of seven isolates under study. These viruses were of two families—Narnaviridae and Totiviridae. Phylogenetic inferences demonstrated that totiviruses from L. adleri and L. tarentolae group together within a larger cluster of LRV2s, while a narnavirus of L. gymnodactyli appeared as a phylogenetic relative of narnaviruses of Blechomonas spp. Taken together, our work not only expanded the range of trypanosomatids that can host RNA viruses but also shed new light on the evolution and potential routes of viral transmission in these flagellates. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00436-023-07928-x.
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spelling pubmed-104955122023-09-13 Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania Klocek, Donnamae Grybchuk, Danyil Tichá, Lucie Votýpka, Jan Volf, Petr Kostygov, Alexei Yu. Yurchenko, Vyacheslav Parasitol Res Research RNA viruses play an important role in Leishmania biology and virulence. Their presence was documented in three (out of four) Leishmania subgenera. Sauroleishmania of reptiles remained the only underinvestigated group. In this work, we analyzed the viral occurrence in Sauroleishmania spp. and detected RNA viruses in three out of seven isolates under study. These viruses were of two families—Narnaviridae and Totiviridae. Phylogenetic inferences demonstrated that totiviruses from L. adleri and L. tarentolae group together within a larger cluster of LRV2s, while a narnavirus of L. gymnodactyli appeared as a phylogenetic relative of narnaviruses of Blechomonas spp. Taken together, our work not only expanded the range of trypanosomatids that can host RNA viruses but also shed new light on the evolution and potential routes of viral transmission in these flagellates. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00436-023-07928-x. Springer Berlin Heidelberg 2023-07-25 2023 /pmc/articles/PMC10495512/ /pubmed/37490143 http://dx.doi.org/10.1007/s00436-023-07928-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Klocek, Donnamae
Grybchuk, Danyil
Tichá, Lucie
Votýpka, Jan
Volf, Petr
Kostygov, Alexei Yu.
Yurchenko, Vyacheslav
Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania
title Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania
title_full Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania
title_fullStr Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania
title_full_unstemmed Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania
title_short Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania
title_sort evolution of rna viruses in trypanosomatids: new insights from the analysis of sauroleishmania
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495512/
https://www.ncbi.nlm.nih.gov/pubmed/37490143
http://dx.doi.org/10.1007/s00436-023-07928-x
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