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Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance
OBJECTIVE: This study investigates whether volumes of intake in the first 24 h of life (24 HOL), in relation to birth weight (BW) and gestational age (GA), impact neonatal feeding intolerance (FI). METHODS: This study employed a retrospective chart review of 6,650 infants born at ≥35 weeks. The volu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495575/ https://www.ncbi.nlm.nih.gov/pubmed/37705598 http://dx.doi.org/10.3389/fped.2023.1245947 |
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author | Kumar, Navin Oredein, Igbagbosanmi Al-Nahar, Mohammed Harris, Nathalee Sampath, Venkatesh |
author_facet | Kumar, Navin Oredein, Igbagbosanmi Al-Nahar, Mohammed Harris, Nathalee Sampath, Venkatesh |
author_sort | Kumar, Navin |
collection | PubMed |
description | OBJECTIVE: This study investigates whether volumes of intake in the first 24 h of life (24 HOL), in relation to birth weight (BW) and gestational age (GA), impact neonatal feeding intolerance (FI). METHODS: This study employed a retrospective chart review of 6,650 infants born at ≥35 weeks. The volumes of each formula feed per kg BW in the first 24 HOL were assessed. FI was defined as evidenced by chart documentation of emesis, abdominal distension, abdominal x-ray, and/or switching to a sensitive formula. RESULTS: Overall, the maximum volume of formula intake per feed was inversely correlated with GA and was higher in infants with FI (β = −1.39, p < 0.001) compared with infants without FI (β = −1.28, p < 0.001). The odds of emesis in late preterm infants with first feeding of >8 ml/kg [adjusted odds ratio (AOR) = 2.5, 95% confidence interval (CI): 1.4–4.6] and formula switching in the exclusively formula-fed group with volumes >10.5 ml/kg [AOR = 2.2, 95% CI (1.8–2.6)] were high. In the breastfeeding group, the odds of FI increased by 2.8-, 4.6-, and 5.2-fold with 5–10, 10–15, and >15 ml/kg of supplementations, respectively. CONCLUSION: A higher volume of intake in relation to BW often exceeds the physiological stomach capacity of newborns and is associated with early FI. Optimizing early feeding volumes based on infant BW and GA may decrease FI, which may be an issue of volume intolerance. |
format | Online Article Text |
id | pubmed-10495575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104955752023-09-13 Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance Kumar, Navin Oredein, Igbagbosanmi Al-Nahar, Mohammed Harris, Nathalee Sampath, Venkatesh Front Pediatr Pediatrics OBJECTIVE: This study investigates whether volumes of intake in the first 24 h of life (24 HOL), in relation to birth weight (BW) and gestational age (GA), impact neonatal feeding intolerance (FI). METHODS: This study employed a retrospective chart review of 6,650 infants born at ≥35 weeks. The volumes of each formula feed per kg BW in the first 24 HOL were assessed. FI was defined as evidenced by chart documentation of emesis, abdominal distension, abdominal x-ray, and/or switching to a sensitive formula. RESULTS: Overall, the maximum volume of formula intake per feed was inversely correlated with GA and was higher in infants with FI (β = −1.39, p < 0.001) compared with infants without FI (β = −1.28, p < 0.001). The odds of emesis in late preterm infants with first feeding of >8 ml/kg [adjusted odds ratio (AOR) = 2.5, 95% confidence interval (CI): 1.4–4.6] and formula switching in the exclusively formula-fed group with volumes >10.5 ml/kg [AOR = 2.2, 95% CI (1.8–2.6)] were high. In the breastfeeding group, the odds of FI increased by 2.8-, 4.6-, and 5.2-fold with 5–10, 10–15, and >15 ml/kg of supplementations, respectively. CONCLUSION: A higher volume of intake in relation to BW often exceeds the physiological stomach capacity of newborns and is associated with early FI. Optimizing early feeding volumes based on infant BW and GA may decrease FI, which may be an issue of volume intolerance. Frontiers Media S.A. 2023-08-29 /pmc/articles/PMC10495575/ /pubmed/37705598 http://dx.doi.org/10.3389/fped.2023.1245947 Text en © 2023 Kumar, Oredein, Al-Nahar, Harris and Sampath. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Kumar, Navin Oredein, Igbagbosanmi Al-Nahar, Mohammed Harris, Nathalee Sampath, Venkatesh Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
title | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
title_full | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
title_fullStr | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
title_full_unstemmed | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
title_short | Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
title_sort | impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495575/ https://www.ncbi.nlm.nih.gov/pubmed/37705598 http://dx.doi.org/10.3389/fped.2023.1245947 |
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