LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway

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Long noncoding RNA (lncRNA) plays crucial roles in the development of gastric cancer (GC); however, studies of their mechanisms of action are needed to determine their clinical value. The aim of this study is to explore the effects and mechanisms of THUMPD3-AS1 in GC. Elevated levels of THUMPD3-AS1...

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Autores principales: Zhang, Zaibo, Li, Yong, Fan, Liqiao, Wang, Bingyu, Liu, Wenbo, Cui, Jiaxiang, Tan, Bibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495635/
https://www.ncbi.nlm.nih.gov/pubmed/37705956
http://dx.doi.org/10.1016/j.isci.2023.107673
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author Zhang, Zaibo
Li, Yong
Fan, Liqiao
Wang, Bingyu
Liu, Wenbo
Cui, Jiaxiang
Tan, Bibo
author_facet Zhang, Zaibo
Li, Yong
Fan, Liqiao
Wang, Bingyu
Liu, Wenbo
Cui, Jiaxiang
Tan, Bibo
author_sort Zhang, Zaibo
collection PubMed
description Long noncoding RNA (lncRNA) plays crucial roles in the development of gastric cancer (GC); however, studies of their mechanisms of action are needed to determine their clinical value. The aim of this study is to explore the effects and mechanisms of THUMPD3-AS1 in GC. Elevated levels of THUMPD3-AS1 were observed in GC and demonstrated a significant positive correlation with poor prognosis. Functionally, THUMPD3-AS1 promoted GC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) and induced tumor growth in vivo. THUMPD3-AS1 exerts its regulatory function on BCAT1 through competitive binding with miR-1297. Further investigations confirmed that both THUMPD3-AS1 and miR-1297 interact with BCAT1. These findings suggest that THUMPD3-AS1 promotes GC invasion and EMT by regulating the miR-1297/BCAT1 pathway, indicating that THUMPD3-AS1 may serve as a biomarker and therapeutic target for GC.
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spelling pubmed-104956352023-09-13 LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway Zhang, Zaibo Li, Yong Fan, Liqiao Wang, Bingyu Liu, Wenbo Cui, Jiaxiang Tan, Bibo iScience Article Long noncoding RNA (lncRNA) plays crucial roles in the development of gastric cancer (GC); however, studies of their mechanisms of action are needed to determine their clinical value. The aim of this study is to explore the effects and mechanisms of THUMPD3-AS1 in GC. Elevated levels of THUMPD3-AS1 were observed in GC and demonstrated a significant positive correlation with poor prognosis. Functionally, THUMPD3-AS1 promoted GC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) and induced tumor growth in vivo. THUMPD3-AS1 exerts its regulatory function on BCAT1 through competitive binding with miR-1297. Further investigations confirmed that both THUMPD3-AS1 and miR-1297 interact with BCAT1. These findings suggest that THUMPD3-AS1 promotes GC invasion and EMT by regulating the miR-1297/BCAT1 pathway, indicating that THUMPD3-AS1 may serve as a biomarker and therapeutic target for GC. Elsevier 2023-08-18 /pmc/articles/PMC10495635/ /pubmed/37705956 http://dx.doi.org/10.1016/j.isci.2023.107673 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhang, Zaibo
Li, Yong
Fan, Liqiao
Wang, Bingyu
Liu, Wenbo
Cui, Jiaxiang
Tan, Bibo
LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway
title LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway
title_full LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway
title_fullStr LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway
title_full_unstemmed LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway
title_short LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway
title_sort lncrna thumpd3-as1 promotes invasion and emt in gastric cancer by regulating the mir-1297/bcat1 pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495635/
https://www.ncbi.nlm.nih.gov/pubmed/37705956
http://dx.doi.org/10.1016/j.isci.2023.107673
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