Cargando…

Association between pancreatic cancer and diabetes: insights from a retrospective cohort study

BACKGROUND: Studies investigating the prevalence of pancreatic cancer have revealed a heightened risk of 1.5 to 2.0 times among individuals with long-standing type 2 diabetes mellitus. AIMS: We aimed to estimate the prevalence of diabetes among patients with pancreatic cancer, and identify the facto...

Descripción completa

Detalles Bibliográficos
Autores principales: Amri, Fakhrddine, Belkhayat, Chifaa, yeznasni, Asmae, Koulali, Hajar, Jabi, Rachid, Zazour, Abdelkrim, Abda, Naima, Bouziane, Mohammed, Ismaili, Zahi, Kharrasse, Ghizlane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496157/
https://www.ncbi.nlm.nih.gov/pubmed/37697301
http://dx.doi.org/10.1186/s12885-023-11344-w
_version_ 1785105047970906112
author Amri, Fakhrddine
Belkhayat, Chifaa
yeznasni, Asmae
Koulali, Hajar
Jabi, Rachid
Zazour, Abdelkrim
Abda, Naima
Bouziane, Mohammed
Ismaili, Zahi
Kharrasse, Ghizlane
author_facet Amri, Fakhrddine
Belkhayat, Chifaa
yeznasni, Asmae
Koulali, Hajar
Jabi, Rachid
Zazour, Abdelkrim
Abda, Naima
Bouziane, Mohammed
Ismaili, Zahi
Kharrasse, Ghizlane
author_sort Amri, Fakhrddine
collection PubMed
description BACKGROUND: Studies investigating the prevalence of pancreatic cancer have revealed a heightened risk of 1.5 to 2.0 times among individuals with long-standing type 2 diabetes mellitus. AIMS: We aimed to estimate the prevalence of diabetes among patients with pancreatic cancer, and identify the factors associated with type 2 diabetes mellitus in this population. METHODS: This retrospective observational and analytical study was carried out in the Department of Gastroenterology of the Mohammed VI University Hospital over a period of 5 years, between 2018 and 2022, including all patients with confirmed cases of pancreatic adenocarcinoma. RESULTS: Out of the 197 patients, 38.1% had a history of diabetes, among them, 42.7% had new-onset diabetes, while the remaining 57.3% had long-standing diabetes. Diabetic patients were significantly older than nondiabetic patients (mean age of 67.2 vs. 63, P = 0.009). Diabetes was more prevalent among obese patients (66.7%, P = 0.01), and less frequent among individuals with chronic alcohol consumption (20% vs. 80%, P = 0.04), and tobacco smokers (24.4% vs75.6%, P = 0.03). Among patients with an ECOG score ≥ 3, DM, 54.5% were DM-patients (P = 0.033). The same significant association was found for the Nutritional Risk Index, Patients who had moderate or severe malnutrition were more likely to be diabetic 74.7% (P = 0.004). Diabetic patients were less likely to undergo surgery due to comorbidities and general health deterioration. However, no significant differences were observed in sex, tumor stage or location. CONCLUSION: Our study has shown an increased prevalence of diabetes in pancreatic cancer and highlights the importance of considering this cancer in cases of recent onset or uncontrolled diabetes, especially in elderly individuals.
format Online
Article
Text
id pubmed-10496157
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-104961572023-09-13 Association between pancreatic cancer and diabetes: insights from a retrospective cohort study Amri, Fakhrddine Belkhayat, Chifaa yeznasni, Asmae Koulali, Hajar Jabi, Rachid Zazour, Abdelkrim Abda, Naima Bouziane, Mohammed Ismaili, Zahi Kharrasse, Ghizlane BMC Cancer Research BACKGROUND: Studies investigating the prevalence of pancreatic cancer have revealed a heightened risk of 1.5 to 2.0 times among individuals with long-standing type 2 diabetes mellitus. AIMS: We aimed to estimate the prevalence of diabetes among patients with pancreatic cancer, and identify the factors associated with type 2 diabetes mellitus in this population. METHODS: This retrospective observational and analytical study was carried out in the Department of Gastroenterology of the Mohammed VI University Hospital over a period of 5 years, between 2018 and 2022, including all patients with confirmed cases of pancreatic adenocarcinoma. RESULTS: Out of the 197 patients, 38.1% had a history of diabetes, among them, 42.7% had new-onset diabetes, while the remaining 57.3% had long-standing diabetes. Diabetic patients were significantly older than nondiabetic patients (mean age of 67.2 vs. 63, P = 0.009). Diabetes was more prevalent among obese patients (66.7%, P = 0.01), and less frequent among individuals with chronic alcohol consumption (20% vs. 80%, P = 0.04), and tobacco smokers (24.4% vs75.6%, P = 0.03). Among patients with an ECOG score ≥ 3, DM, 54.5% were DM-patients (P = 0.033). The same significant association was found for the Nutritional Risk Index, Patients who had moderate or severe malnutrition were more likely to be diabetic 74.7% (P = 0.004). Diabetic patients were less likely to undergo surgery due to comorbidities and general health deterioration. However, no significant differences were observed in sex, tumor stage or location. CONCLUSION: Our study has shown an increased prevalence of diabetes in pancreatic cancer and highlights the importance of considering this cancer in cases of recent onset or uncontrolled diabetes, especially in elderly individuals. BioMed Central 2023-09-11 /pmc/articles/PMC10496157/ /pubmed/37697301 http://dx.doi.org/10.1186/s12885-023-11344-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Amri, Fakhrddine
Belkhayat, Chifaa
yeznasni, Asmae
Koulali, Hajar
Jabi, Rachid
Zazour, Abdelkrim
Abda, Naima
Bouziane, Mohammed
Ismaili, Zahi
Kharrasse, Ghizlane
Association between pancreatic cancer and diabetes: insights from a retrospective cohort study
title Association between pancreatic cancer and diabetes: insights from a retrospective cohort study
title_full Association between pancreatic cancer and diabetes: insights from a retrospective cohort study
title_fullStr Association between pancreatic cancer and diabetes: insights from a retrospective cohort study
title_full_unstemmed Association between pancreatic cancer and diabetes: insights from a retrospective cohort study
title_short Association between pancreatic cancer and diabetes: insights from a retrospective cohort study
title_sort association between pancreatic cancer and diabetes: insights from a retrospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496157/
https://www.ncbi.nlm.nih.gov/pubmed/37697301
http://dx.doi.org/10.1186/s12885-023-11344-w
work_keys_str_mv AT amrifakhrddine associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy
AT belkhayatchifaa associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy
AT yeznasniasmae associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy
AT koulalihajar associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy
AT jabirachid associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy
AT zazourabdelkrim associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy
AT abdanaima associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy
AT bouzianemohammed associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy
AT ismailizahi associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy
AT kharrasseghizlane associationbetweenpancreaticcanceranddiabetesinsightsfromaretrospectivecohortstudy