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Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders
BACKGROUND: Recently, a systematic review and meta-analysis demonstrated that overexpression of p53 immunoprotein was significantly associated with progression risk of oral potentially malignant disorders (OPMD). However, the results of investigations on TP53 genetic typing in OPMD were inconsistent...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496165/ https://www.ncbi.nlm.nih.gov/pubmed/37697274 http://dx.doi.org/10.1186/s12903-023-03316-0 |
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author | Li, Huangkai Liu, Yu Zhou, Shanxin Zhou, Qin Yang, Xi |
author_facet | Li, Huangkai Liu, Yu Zhou, Shanxin Zhou, Qin Yang, Xi |
author_sort | Li, Huangkai |
collection | PubMed |
description | BACKGROUND: Recently, a systematic review and meta-analysis demonstrated that overexpression of p53 immunoprotein was significantly associated with progression risk of oral potentially malignant disorders (OPMD). However, the results of investigations on TP53 genetic typing in OPMD were inconsistent and inconclusive. METHODS: A systematic evaluation was conducted to identify all eligible case–control studies on the association of TP53 codon 72 polymorphism with both onset and progression of OPMD. RESULTS: A total of 768 OPMD patients and 1173 healthy individuals were identified from 12 eligible case–control studies on TP53 codon 72 polymorphism OPMD onset. In overall and subgroup analyses, no significantly risk of OPMD onset was observed in the cases for genetic models including allele C vs. G, homozygote CC vs. GG, heterozygote GC vs. GG, dominant GC + CC vs. GG, and recessive CC vs. GG + GC (all P-value of association test > 0.05). Further, a total of 465 OPMD patients and 775 oral squamous cell carcinoma (OSCC) ones were identified from 8 eligible case–control studies on this polymorphism in OPMD progression to OSCC. The analyses revealed that there was also no significantly risk of OPMD progression in the cases for the genetic models (all P-value of association test > 0.05). CONCLUSION: Our data of a pooled-analysis indicates that TP53 codon 72 polymorphism may not act as genetic factor for the risk of OPMD onset and progression. Combined with the conclusion by a systematic review and meta-analysis, we put forward a new opinion that TP53 genetic typing cloud not influence p53 protein expression in OPMD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12903-023-03316-0. |
format | Online Article Text |
id | pubmed-10496165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104961652023-09-13 Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders Li, Huangkai Liu, Yu Zhou, Shanxin Zhou, Qin Yang, Xi BMC Oral Health Research BACKGROUND: Recently, a systematic review and meta-analysis demonstrated that overexpression of p53 immunoprotein was significantly associated with progression risk of oral potentially malignant disorders (OPMD). However, the results of investigations on TP53 genetic typing in OPMD were inconsistent and inconclusive. METHODS: A systematic evaluation was conducted to identify all eligible case–control studies on the association of TP53 codon 72 polymorphism with both onset and progression of OPMD. RESULTS: A total of 768 OPMD patients and 1173 healthy individuals were identified from 12 eligible case–control studies on TP53 codon 72 polymorphism OPMD onset. In overall and subgroup analyses, no significantly risk of OPMD onset was observed in the cases for genetic models including allele C vs. G, homozygote CC vs. GG, heterozygote GC vs. GG, dominant GC + CC vs. GG, and recessive CC vs. GG + GC (all P-value of association test > 0.05). Further, a total of 465 OPMD patients and 775 oral squamous cell carcinoma (OSCC) ones were identified from 8 eligible case–control studies on this polymorphism in OPMD progression to OSCC. The analyses revealed that there was also no significantly risk of OPMD progression in the cases for the genetic models (all P-value of association test > 0.05). CONCLUSION: Our data of a pooled-analysis indicates that TP53 codon 72 polymorphism may not act as genetic factor for the risk of OPMD onset and progression. Combined with the conclusion by a systematic review and meta-analysis, we put forward a new opinion that TP53 genetic typing cloud not influence p53 protein expression in OPMD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12903-023-03316-0. BioMed Central 2023-09-12 /pmc/articles/PMC10496165/ /pubmed/37697274 http://dx.doi.org/10.1186/s12903-023-03316-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Li, Huangkai Liu, Yu Zhou, Shanxin Zhou, Qin Yang, Xi Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
title | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
title_full | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
title_fullStr | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
title_full_unstemmed | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
title_short | Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
title_sort | systematic evaluation of tp53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496165/ https://www.ncbi.nlm.nih.gov/pubmed/37697274 http://dx.doi.org/10.1186/s12903-023-03316-0 |
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