N-Acetylcysteine overcomes epalrestat-mediated increase of toxic 4-hydroxy-2-nonenal and potentiates the anti-arthritic effect of epalrestat in AIA model

Epalrestat, an aldose reductase inhibitor (ARI), has been clinically adopted in treating diabetic neuropathy in China and Japan. Apart from the involvement in diabetic complications, AR has been implicated in inflammation. Here, we seek to investigate the feasibility of clinically approved ARI, epal...

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Detalles Bibliográficos
Autores principales: Wang, Linna, Huang, Baixiong, Zeng, Yaling, Yang, Jiujie, Li, Zhi, Ng, Jerome P. L., Xu, Xiongfei, Su, Lu, Yun, Xiaoyun, Qu, Liqun, Chen, Ruihong, Luo, Weidan, Wang, Yuping, Chen, Chang, Yang, Lijun, Qu, Yuanqing, Zhang, Wei, Chan, Joyce Tsz Wai, Wang, Xingxia, Law, Betty Yuen Kwan, Mok, Simon Wing Fai, Chung, Sookja Kim, Wong, Vincent Kam Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496504/
https://www.ncbi.nlm.nih.gov/pubmed/37705749
http://dx.doi.org/10.7150/ijbs.85028

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