Sirtuin-3 activates the mitochondrial unfolded protein response and reduces cerebral ischemia/reperfusion injury

Sirtuin-3 (Sirt3) deacetylates several mitochondrial proteins implicated into cerebral ischemia/reperfusion (I/R) injury. The mitochondrial unfolded protein response (UPR(mt)) favors mitochondrial proteostasis during various stressors. Here, we used Sirt3 transgenic mice and a transient middle cereb...

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Detalles Bibliográficos
Autores principales: Xiaowei, Xie, Qian, Xu, Dingzhou, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496505/
https://www.ncbi.nlm.nih.gov/pubmed/37705748
http://dx.doi.org/10.7150/ijbs.86614

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