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Coculture of cancer cells with platelets increases their survival and metastasis by activating the TGFβ/Smad/PAI-1 and PI3K/AKT pathways

When cancer cells enter the bloodstream, they can interact with platelets to acquire stronger survival and metastatic abilities. To elucidate the underlying mechanisms, we cocultured metastatic melanoma and triple-negative breast cancer cells with species-homologous platelets. We found that cocultur...

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Detalles Bibliográficos
Autores principales:	Tong, Haibo, Li, Koukou, Zhou, Muya, Wu, Renfei, Yang, Hongmei, Peng, Zheng, Zhao, Qi, Luo, Kathy Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496510/ https://www.ncbi.nlm.nih.gov/pubmed/37705745 http://dx.doi.org/10.7150/ijbs.85986

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