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DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells

Though DNMTs inhibitors were widely used in myelodysplastic syndrome and leukaemia, their application in solid tumours has been limited by low response rate and lack of optimal combination strategies. In gastric cancer (GC), the therapeutic implication of KRAS mutation or MEK/ERK activation for comb...

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Detalles Bibliográficos
Autores principales:	Chen, Zhangqian, Zhang, Lin, Yang, Yang, Liu, Haiming, Kang, Xiaoyu, Nie, Yongzhan, Fan, Daiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496526/ https://www.ncbi.nlm.nih.gov/pubmed/37691391 http://dx.doi.org/10.1080/15592294.2023.2254976

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