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The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia: O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada
CONTEXT AND OBJECTIVE: Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG), tota...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Associação Paulista de Medicina - APM
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496609/ https://www.ncbi.nlm.nih.gov/pubmed/27191247 http://dx.doi.org/10.1590/1516-3180.2015.01702312 |
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author | Argani, Hassan Ghorbanihaghjo, Amir Vatankhahan, Hamid Rashtchizadeh, Nadereh Raeisi, Sina Ilghami, Hadi |
author_facet | Argani, Hassan Ghorbanihaghjo, Amir Vatankhahan, Hamid Rashtchizadeh, Nadereh Raeisi, Sina Ilghami, Hadi |
author_sort | Argani, Hassan |
collection | PubMed |
description | CONTEXT AND OBJECTIVE: Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (apo-AI) levels and paraoxonase (PON) activity in patients with mild to moderate hyperlipidemia (MMH). DESIGN AND SETTINGS: A randomized double-blind placebo-controlled clinical trial was conducted at Shahid-Modarres Hospital (Tehran, Iran) and Tabriz University of Medical Sciences. Seventy MMH patients were randomly assigned to receive treatment (200 mg/day of RGSE) or placebo for eight weeks. RESULTS: Significant elevation in serum levels of apo-AI (P = 0.001), HDL-C (P = 0.001) and PON activity (P = 0.001) and marked decreases in concentrations of TC (P = 0.015), TG (P = 0.011) and LDL-C (P = 0.014) were found in the cases. PON activity was significantly correlated with apo-AI (r = 0.270; P < 0.01) and HDL-C (r = 0.45; P < 0.001). Significant differences between the RGSE and control groups (before and after treatment) for TC (P = 0.001), TG (P = 0.001), PON (P = 0.03), apo-AI (P = 0.001) and LDL-C (P = 0.002) were seen. CONCLUSION: It is possible that RGSE increases PON activity mostly through increasing HDL-C and apo-AI levels in MMH patients. It may thus have potential beneficial effects in preventing oxidative stress and atherosclerosis in these patients. |
format | Online Article Text |
id | pubmed-10496609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Associação Paulista de Medicina - APM |
record_format | MEDLINE/PubMed |
spelling | pubmed-104966092023-09-13 The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia: O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada Argani, Hassan Ghorbanihaghjo, Amir Vatankhahan, Hamid Rashtchizadeh, Nadereh Raeisi, Sina Ilghami, Hadi Sao Paulo Med J Original Article CONTEXT AND OBJECTIVE: Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (apo-AI) levels and paraoxonase (PON) activity in patients with mild to moderate hyperlipidemia (MMH). DESIGN AND SETTINGS: A randomized double-blind placebo-controlled clinical trial was conducted at Shahid-Modarres Hospital (Tehran, Iran) and Tabriz University of Medical Sciences. Seventy MMH patients were randomly assigned to receive treatment (200 mg/day of RGSE) or placebo for eight weeks. RESULTS: Significant elevation in serum levels of apo-AI (P = 0.001), HDL-C (P = 0.001) and PON activity (P = 0.001) and marked decreases in concentrations of TC (P = 0.015), TG (P = 0.011) and LDL-C (P = 0.014) were found in the cases. PON activity was significantly correlated with apo-AI (r = 0.270; P < 0.01) and HDL-C (r = 0.45; P < 0.001). Significant differences between the RGSE and control groups (before and after treatment) for TC (P = 0.001), TG (P = 0.001), PON (P = 0.03), apo-AI (P = 0.001) and LDL-C (P = 0.002) were seen. CONCLUSION: It is possible that RGSE increases PON activity mostly through increasing HDL-C and apo-AI levels in MMH patients. It may thus have potential beneficial effects in preventing oxidative stress and atherosclerosis in these patients. Associação Paulista de Medicina - APM 2016-05-13 /pmc/articles/PMC10496609/ /pubmed/27191247 http://dx.doi.org/10.1590/1516-3180.2015.01702312 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons license. |
spellingShingle | Original Article Argani, Hassan Ghorbanihaghjo, Amir Vatankhahan, Hamid Rashtchizadeh, Nadereh Raeisi, Sina Ilghami, Hadi The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia: O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada |
title | The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia: O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada |
title_full | The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia: O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada |
title_fullStr | The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia: O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada |
title_full_unstemmed | The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia: O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada |
title_short | The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia: O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada |
title_sort | effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia: o efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496609/ https://www.ncbi.nlm.nih.gov/pubmed/27191247 http://dx.doi.org/10.1590/1516-3180.2015.01702312 |
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