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Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts

BACKGROUND: Immunosuppressive drugs such as tacrolimus have revolutionized our ability to transplant organs between individuals. Tacrolimus acts systemically to suppress the activity of T-cells within and around transplanted organs. However, tacrolimus also suppresses T-cell function in the skin, co...

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Detalles Bibliográficos
Autores principales:	Veitch, Margaret, Beaumont, Kimberly, Pouwer, Rebecca, Chew, Hui Yi, Frazer, Ian H, Soyer, H Peter, Campbell, Scott, Dymock, Brian W, Harvey, Andrew, Cock, Terrie-Anne, Wells, James W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496666/ https://www.ncbi.nlm.nih.gov/pubmed/37678918 http://dx.doi.org/10.1136/jitc-2023-006783

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