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Targeting T-cell malignancies using allogeneic double-negative CD4-CAR-T cells

BACKGROUND: Patients with relapsed/refractory T-cell malignancies have limited treatment options. The use of chimeric antigen receptor (CAR)-T cell therapy for T-cell malignancies is challenging due to possible blast contamination of autologous T-cell products and fratricide of CAR-T cells targeting...

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Detalles Bibliográficos
Autores principales:	Fang, Karen Kai-Lin, Lee, Jongbok, Khatri, Ismat, Na, Yoosu, Zhang, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496713/ https://www.ncbi.nlm.nih.gov/pubmed/37678917 http://dx.doi.org/10.1136/jitc-2023-007277

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