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Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study

CONTEXT AND OBJECTIVE: Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients. DESIGN AN...

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Autores principales: Ventura, Aline, Ronsoni, Marcelo Fernando, Shiozawa, Maria Beatriz Cacese, Dantas-Corrêa, Esther Buzaglo, Canalli, Maria Heloisa Busi da Silva, Schiavon, Leonardo de Lucca, Narciso-Schiavon, Janaína Luz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Paulista de Medicina - APM 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496779/
https://www.ncbi.nlm.nih.gov/pubmed/25351758
http://dx.doi.org/10.1590/1516-3180-2014-1326725
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author Ventura, Aline
Ronsoni, Marcelo Fernando
Shiozawa, Maria Beatriz Cacese
Dantas-Corrêa, Esther Buzaglo
Canalli, Maria Heloisa Busi da Silva
Schiavon, Leonardo de Lucca
Narciso-Schiavon, Janaína Luz
author_facet Ventura, Aline
Ronsoni, Marcelo Fernando
Shiozawa, Maria Beatriz Cacese
Dantas-Corrêa, Esther Buzaglo
Canalli, Maria Heloisa Busi da Silva
Schiavon, Leonardo de Lucca
Narciso-Schiavon, Janaína Luz
author_sort Ventura, Aline
collection PubMed
description CONTEXT AND OBJECTIVE: Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: This cross-sectional prevalence study included autoimmune thyroiditis patients who were tested for anti-endomysial and anti-transglutaminase antibodies between August 2010 and July 2011. RESULTS: Fifty-three patients with autoimmune thyroiditis were included; 92.5% were women, with mean age of 49.0 ± 13.5 years. Five patients (9.3%) were serologically positive for celiac disease: three of them (5.6%) were reactive for anti-endomysial antibodies and two (3.7%) for anti-transglutaminase. None of them exhibited anemia and one presented diarrhea. Endoscopy was performed on two patients: one with normal histology and the other with lymphocytic infiltrate and villous atrophy. CONCLUSION: The prevalence of celiac disease among patients with autoimmune thyroid disease was 9.3%; one patient complained of diarrhea and none presented anemia. Among at-risk populations, like autoimmune thyroiditis patients, the presence of diarrhea or anemia should not be used as a criterion for indicating celiac disease investigation. This must be done for all autoimmune thyroiditis patients because of its high prevalence.
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spelling pubmed-104967792023-09-13 Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study Ventura, Aline Ronsoni, Marcelo Fernando Shiozawa, Maria Beatriz Cacese Dantas-Corrêa, Esther Buzaglo Canalli, Maria Heloisa Busi da Silva Schiavon, Leonardo de Lucca Narciso-Schiavon, Janaína Luz Sao Paulo Med J Original Article CONTEXT AND OBJECTIVE: Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: This cross-sectional prevalence study included autoimmune thyroiditis patients who were tested for anti-endomysial and anti-transglutaminase antibodies between August 2010 and July 2011. RESULTS: Fifty-three patients with autoimmune thyroiditis were included; 92.5% were women, with mean age of 49.0 ± 13.5 years. Five patients (9.3%) were serologically positive for celiac disease: three of them (5.6%) were reactive for anti-endomysial antibodies and two (3.7%) for anti-transglutaminase. None of them exhibited anemia and one presented diarrhea. Endoscopy was performed on two patients: one with normal histology and the other with lymphocytic infiltrate and villous atrophy. CONCLUSION: The prevalence of celiac disease among patients with autoimmune thyroid disease was 9.3%; one patient complained of diarrhea and none presented anemia. Among at-risk populations, like autoimmune thyroiditis patients, the presence of diarrhea or anemia should not be used as a criterion for indicating celiac disease investigation. This must be done for all autoimmune thyroiditis patients because of its high prevalence. Associação Paulista de Medicina - APM 2014-09-02 /pmc/articles/PMC10496779/ /pubmed/25351758 http://dx.doi.org/10.1590/1516-3180-2014-1326725 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons license.
spellingShingle Original Article
Ventura, Aline
Ronsoni, Marcelo Fernando
Shiozawa, Maria Beatriz Cacese
Dantas-Corrêa, Esther Buzaglo
Canalli, Maria Heloisa Busi da Silva
Schiavon, Leonardo de Lucca
Narciso-Schiavon, Janaína Luz
Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study
title Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study
title_full Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study
title_fullStr Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study
title_full_unstemmed Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study
title_short Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study
title_sort prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496779/
https://www.ncbi.nlm.nih.gov/pubmed/25351758
http://dx.doi.org/10.1590/1516-3180-2014-1326725
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