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The role of ion channels in T cell function and disease
T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of ca...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497217/ https://www.ncbi.nlm.nih.gov/pubmed/37705981 http://dx.doi.org/10.3389/fimmu.2023.1238171 |
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author | Manolios, Nicholas Papaemmanouil, John Adams, David J. |
author_facet | Manolios, Nicholas Papaemmanouil, John Adams, David J. |
author_sort | Manolios, Nicholas |
collection | PubMed |
description | T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of cancer growth, and autoimmune diseases. Ion channels play a critical role in the regulation of T cell signaling and cellular function and are often overlooked and understudied. Little is known about the ion “channelome” and the interaction of ion channels in immune cells. This review aims to summarize the published data on the impact of ion channels on T cell function and disease. The importance of ion channels in health and disease plus the fact they are easily accessible by virtue of being expressed on the surface of plasma membranes makes them excellent drug targets. |
format | Online Article Text |
id | pubmed-10497217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104972172023-09-13 The role of ion channels in T cell function and disease Manolios, Nicholas Papaemmanouil, John Adams, David J. Front Immunol Immunology T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of cancer growth, and autoimmune diseases. Ion channels play a critical role in the regulation of T cell signaling and cellular function and are often overlooked and understudied. Little is known about the ion “channelome” and the interaction of ion channels in immune cells. This review aims to summarize the published data on the impact of ion channels on T cell function and disease. The importance of ion channels in health and disease plus the fact they are easily accessible by virtue of being expressed on the surface of plasma membranes makes them excellent drug targets. Frontiers Media S.A. 2023-08-29 /pmc/articles/PMC10497217/ /pubmed/37705981 http://dx.doi.org/10.3389/fimmu.2023.1238171 Text en Copyright © 2023 Manolios, Papaemmanouil and Adams https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Manolios, Nicholas Papaemmanouil, John Adams, David J. The role of ion channels in T cell function and disease |
title | The role of ion channels in T cell function and disease |
title_full | The role of ion channels in T cell function and disease |
title_fullStr | The role of ion channels in T cell function and disease |
title_full_unstemmed | The role of ion channels in T cell function and disease |
title_short | The role of ion channels in T cell function and disease |
title_sort | role of ion channels in t cell function and disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497217/ https://www.ncbi.nlm.nih.gov/pubmed/37705981 http://dx.doi.org/10.3389/fimmu.2023.1238171 |
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