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Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America
PURPOSE: Despite strong induction chemotherapy response rates, only 30%-40% of patients with adult B-cell acute lymphoblastic leukemia (ALL) attain long-term remission. This study analyzes ALL in Latin America (LA) and recommends diagnosis, treatment, and management protocols. METHODS: The Americas...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497277/ https://www.ncbi.nlm.nih.gov/pubmed/37167576 http://dx.doi.org/10.1200/GO.22.00292 |
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author | Basquiera, Ana Lisa Seiwald, Maria Cristina Best Aguilera, Carlos Roberto Enciso, Leonardo Fernandez, Isolda Jansen, Angela Marie Nunes, Elenaide Sanchez del Villar, Matias Urbalejo Ceniceros, Victor I. Rocha, Vanderson |
author_facet | Basquiera, Ana Lisa Seiwald, Maria Cristina Best Aguilera, Carlos Roberto Enciso, Leonardo Fernandez, Isolda Jansen, Angela Marie Nunes, Elenaide Sanchez del Villar, Matias Urbalejo Ceniceros, Victor I. Rocha, Vanderson |
author_sort | Basquiera, Ana Lisa |
collection | PubMed |
description | PURPOSE: Despite strong induction chemotherapy response rates, only 30%-40% of patients with adult B-cell acute lymphoblastic leukemia (ALL) attain long-term remission. This study analyzes ALL in Latin America (LA) and recommends diagnosis, treatment, and management protocols. METHODS: The Americas Health Foundation organized a panel of hematologists from Argentina, Brazil, Chile, Colombia, and Mexico to examine ALL diagnosis and therapy and produce recommendations. RESULTS: Lack of regional data, unequal access to diagnosis and therapy, inadequate treatment response, and uneven health care distribution complicate adult ALL management. The panel recommended diagnosis, first-line and refractory treatment, and post-transplantation maintenance. Targeted treatments, including rituximab, blinatumomab, and inotuzumab ozogamicin, are becoming available in LA and must be equitably accessed. CONCLUSION: This review adapts global information on treating ALL to LA. Governments, the medical community, society, academia, industry, and patient advocates must work together to improve policies. |
format | Online Article Text |
id | pubmed-10497277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-104972772023-09-13 Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America Basquiera, Ana Lisa Seiwald, Maria Cristina Best Aguilera, Carlos Roberto Enciso, Leonardo Fernandez, Isolda Jansen, Angela Marie Nunes, Elenaide Sanchez del Villar, Matias Urbalejo Ceniceros, Victor I. Rocha, Vanderson JCO Glob Oncol REVIEW ARTICLES PURPOSE: Despite strong induction chemotherapy response rates, only 30%-40% of patients with adult B-cell acute lymphoblastic leukemia (ALL) attain long-term remission. This study analyzes ALL in Latin America (LA) and recommends diagnosis, treatment, and management protocols. METHODS: The Americas Health Foundation organized a panel of hematologists from Argentina, Brazil, Chile, Colombia, and Mexico to examine ALL diagnosis and therapy and produce recommendations. RESULTS: Lack of regional data, unequal access to diagnosis and therapy, inadequate treatment response, and uneven health care distribution complicate adult ALL management. The panel recommended diagnosis, first-line and refractory treatment, and post-transplantation maintenance. Targeted treatments, including rituximab, blinatumomab, and inotuzumab ozogamicin, are becoming available in LA and must be equitably accessed. CONCLUSION: This review adapts global information on treating ALL to LA. Governments, the medical community, society, academia, industry, and patient advocates must work together to improve policies. Wolters Kluwer Health 2023-05-11 /pmc/articles/PMC10497277/ /pubmed/37167576 http://dx.doi.org/10.1200/GO.22.00292 Text en © 2023 by American Society of Clinical Oncology https://creativecommons.org/licenses/by/4.0/Licensed under the Creative Commons Attribution 4.0 License: http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | REVIEW ARTICLES Basquiera, Ana Lisa Seiwald, Maria Cristina Best Aguilera, Carlos Roberto Enciso, Leonardo Fernandez, Isolda Jansen, Angela Marie Nunes, Elenaide Sanchez del Villar, Matias Urbalejo Ceniceros, Victor I. Rocha, Vanderson Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
title | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
title_full | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
title_fullStr | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
title_full_unstemmed | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
title_short | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
title_sort | expert recommendations for the diagnosis, treatment, and management of adult b-cell acute lymphoblastic leukemia in latin america |
topic | REVIEW ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497277/ https://www.ncbi.nlm.nih.gov/pubmed/37167576 http://dx.doi.org/10.1200/GO.22.00292 |
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