Cargando…
Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss
Profound congenital sensorineural hearing loss (SNHL) prevents children from developing spoken language. Cochlear implantation and auditory brainstem implantation can provide partial hearing sensation, but language development outcomes can vary, particularly for patients with inner ear malformations...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497283/ https://www.ncbi.nlm.nih.gov/pubmed/37697742 http://dx.doi.org/10.7554/eLife.85983 |
_version_ | 1785105272435376128 |
---|---|
author | Wang, Yaoxuan Jiang, Mengda Zhu, Yuting Xue, Lu Shu, Wenying Li, Xiang Chen, Hongsai Li, Yun Chen, Ying Chai, Yongchuan Zhang, Yu Chu, Yinghua Song, Yang Tao, Xiaofeng Wang, Zhaoyan Wu, Hao |
author_facet | Wang, Yaoxuan Jiang, Mengda Zhu, Yuting Xue, Lu Shu, Wenying Li, Xiang Chen, Hongsai Li, Yun Chen, Ying Chai, Yongchuan Zhang, Yu Chu, Yinghua Song, Yang Tao, Xiaofeng Wang, Zhaoyan Wu, Hao |
author_sort | Wang, Yaoxuan |
collection | PubMed |
description | Profound congenital sensorineural hearing loss (SNHL) prevents children from developing spoken language. Cochlear implantation and auditory brainstem implantation can provide partial hearing sensation, but language development outcomes can vary, particularly for patients with inner ear malformations and/or cochlear nerve deficiency (IEM&CND). Currently, the peripheral auditory structure is evaluated through visual inspection of clinical imaging, but this method is insufficient for surgical planning and prognosis. The central auditory pathway is also challenging to examine in vivo due to its delicate subcortical structures. Previous attempts to locate subcortical auditory nuclei using fMRI responses to sounds are not applicable to patients with profound hearing loss as no auditory brainstem responses can be detected in these individuals, making it impossible to capture corresponding blood oxygen signals in fMRI. In this study, we developed a new pipeline for mapping the auditory pathway using structural and diffusional MRI. We used a fixel-based approach to investigate the structural development of the auditory-language network for profound SNHL children with normal peripheral structure and those with IEM&CND under 6 years old. Our findings indicate that the language pathway is more sensitive to peripheral auditory condition than the central auditory pathway, highlighting the importance of early intervention for profound SNHL children to provide timely speech inputs. We also propose a comprehensive pre-surgical evaluation extending from the cochlea to the auditory-language network, showing significant correlations between age, gender, Cn.VIII median contrast value, and the language network with post-implant qualitative outcomes. |
format | Online Article Text |
id | pubmed-10497283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-104972832023-09-13 Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss Wang, Yaoxuan Jiang, Mengda Zhu, Yuting Xue, Lu Shu, Wenying Li, Xiang Chen, Hongsai Li, Yun Chen, Ying Chai, Yongchuan Zhang, Yu Chu, Yinghua Song, Yang Tao, Xiaofeng Wang, Zhaoyan Wu, Hao eLife Neuroscience Profound congenital sensorineural hearing loss (SNHL) prevents children from developing spoken language. Cochlear implantation and auditory brainstem implantation can provide partial hearing sensation, but language development outcomes can vary, particularly for patients with inner ear malformations and/or cochlear nerve deficiency (IEM&CND). Currently, the peripheral auditory structure is evaluated through visual inspection of clinical imaging, but this method is insufficient for surgical planning and prognosis. The central auditory pathway is also challenging to examine in vivo due to its delicate subcortical structures. Previous attempts to locate subcortical auditory nuclei using fMRI responses to sounds are not applicable to patients with profound hearing loss as no auditory brainstem responses can be detected in these individuals, making it impossible to capture corresponding blood oxygen signals in fMRI. In this study, we developed a new pipeline for mapping the auditory pathway using structural and diffusional MRI. We used a fixel-based approach to investigate the structural development of the auditory-language network for profound SNHL children with normal peripheral structure and those with IEM&CND under 6 years old. Our findings indicate that the language pathway is more sensitive to peripheral auditory condition than the central auditory pathway, highlighting the importance of early intervention for profound SNHL children to provide timely speech inputs. We also propose a comprehensive pre-surgical evaluation extending from the cochlea to the auditory-language network, showing significant correlations between age, gender, Cn.VIII median contrast value, and the language network with post-implant qualitative outcomes. eLife Sciences Publications, Ltd 2023-09-12 /pmc/articles/PMC10497283/ /pubmed/37697742 http://dx.doi.org/10.7554/eLife.85983 Text en © 2023, Wang, Jiang, Zhu et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Wang, Yaoxuan Jiang, Mengda Zhu, Yuting Xue, Lu Shu, Wenying Li, Xiang Chen, Hongsai Li, Yun Chen, Ying Chai, Yongchuan Zhang, Yu Chu, Yinghua Song, Yang Tao, Xiaofeng Wang, Zhaoyan Wu, Hao Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss |
title | Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss |
title_full | Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss |
title_fullStr | Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss |
title_full_unstemmed | Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss |
title_short | Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss |
title_sort | impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497283/ https://www.ncbi.nlm.nih.gov/pubmed/37697742 http://dx.doi.org/10.7554/eLife.85983 |
work_keys_str_mv | AT wangyaoxuan impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT jiangmengda impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT zhuyuting impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT xuelu impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT shuwenying impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT lixiang impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT chenhongsai impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT liyun impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT chenying impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT chaiyongchuan impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT zhangyu impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT chuyinghua impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT songyang impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT taoxiaofeng impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT wangzhaoyan impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss AT wuhao impactofinnerearmalformationandcochlearnervedeficiencyonthedevelopmentofauditorylanguagenetworkinchildrenwithprofoundsensorineuralhearingloss |