Protein ISGylation: a posttranslational modification with implications for malignant neoplasms

Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational modification can modulate the stability of the ISGylated proteins and protein-protein interactions. S...

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Detalles Bibliográficos
Autores principales: Tecalco-Cruz, Angeles C., Zepeda-Cervantes, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497404/
https://www.ncbi.nlm.nih.gov/pubmed/37711589
http://dx.doi.org/10.37349/etat.2023.00162
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author Tecalco-Cruz, Angeles C.
Zepeda-Cervantes, Jesús
author_facet Tecalco-Cruz, Angeles C.
Zepeda-Cervantes, Jesús
author_sort Tecalco-Cruz, Angeles C.
collection PubMed
description Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational modification can modulate the stability of the ISGylated proteins and protein-protein interactions. Some proteins modified by ISG15 have been identified in malignant neoplasms, suggesting the functional relevance of ISGylation in cancer. This review discusses the ISGylated proteins reported in malignant neoplasms that suggest the potential of ISG15 as a biomarker and therapeutic target in cancer.
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spelling pubmed-104974042023-09-14 Protein ISGylation: a posttranslational modification with implications for malignant neoplasms Tecalco-Cruz, Angeles C. Zepeda-Cervantes, Jesús Explor Target Antitumor Ther Review Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational modification can modulate the stability of the ISGylated proteins and protein-protein interactions. Some proteins modified by ISG15 have been identified in malignant neoplasms, suggesting the functional relevance of ISGylation in cancer. This review discusses the ISGylated proteins reported in malignant neoplasms that suggest the potential of ISG15 as a biomarker and therapeutic target in cancer. Open Exploration Publishing 2023 2023-08-31 /pmc/articles/PMC10497404/ /pubmed/37711589 http://dx.doi.org/10.37349/etat.2023.00162 Text en © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Tecalco-Cruz, Angeles C.
Zepeda-Cervantes, Jesús
Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
title Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
title_full Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
title_fullStr Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
title_full_unstemmed Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
title_short Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
title_sort protein isgylation: a posttranslational modification with implications for malignant neoplasms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497404/
https://www.ncbi.nlm.nih.gov/pubmed/37711589
http://dx.doi.org/10.37349/etat.2023.00162
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