Cargando…

Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization

The third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope glycoprotein trimer is indispensable for virus cell entry. Conformational masking of V3 within the trimer allows efficient neutralization via V3 only by rare, broadly neutralizing glycan-dependent antibodies targetin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glögl, Matthias, Friedrich, Nikolas, Cerutti, Gabriele, Lemmin, Thomas, Kwon, Young D., Gorman, Jason, Maliqi, Liridona, Mittl, Peer R. E., Hesselman, Maria C., Schmidt, Daniel, Weber, Jacqueline, Foulkes, Caio, Dingens, Adam S., Bylund, Tatsiana, Olia, Adam S., Verardi, Raffaello, Reinberg, Thomas, Baumann, Nicolas S., Rusert, Peter, Dreier, Birgit, Shapiro, Lawrence, Kwong, Peter D., Plückthun, Andreas, Trkola, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497408/ https://www.ncbi.nlm.nih.gov/pubmed/37605043 http://dx.doi.org/10.1038/s41594-023-01062-z

Ejemplares similares

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
por: Friedrich, Nikolas, et al.
Publicado: (2021)

Assessing immunogenicity barriers of the HIV-1 envelope trimer
por: Maliqi, Liridona, et al.
Publicado: (2023)

Conformation-dependent recognition of HIV Gp120 by DARPins provides novel possibilities to develop distinct HIV entry inhibitors
por: Mann, AM, et al.
Publicado: (2012)

Structural analysis of biological targets by host:guest crystal lattice engineering
por: Ernst, Patrick, et al.
Publicado: (2019)

Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5
por: Radom, Filip, et al.
Publicado: (2021)

The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection
por: Bieri, Manuela, et al.
Publicado: (2021)

P02-09. Dissecting the interference of endotoxins with HIV infection of primary CD4 T cell
por: Krarup, A, et al.
Publicado: (2009)

P04-40. Dissecting pre- and post-attachment activity of HIV-1 entry inhibitors and neutralizing antibodies
por: Berlinger, L, et al.
Publicado: (2009)

Rigidly connected multispecific artificial binders with adjustable geometries
por: Wu, Yufan, et al.
Publicado: (2017)

Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects
por: Reichen, Christian, et al.
Publicado: (2016)

Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts
por: Ernst, Patrick, et al.
Publicado: (2019)

Different Infectivity of HIV-1 Strains Is Linked to Number of Envelope Trimers Required for Entry
por: Brandenberg, Oliver F., et al.
Publicado: (2015)

Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity
por: Abela, Irene A., et al.
Publicado: (2021)

Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent
por: Reh, Lucia, et al.
Publicado: (2015)

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters
por: Brandenberg, Oliver F., et al.
Publicado: (2017)

Cell-Cell Transmission Enables HIV-1 to Evade Inhibition by Potent CD4bs Directed Antibodies
por: Abela, Irene A., et al.
Publicado: (2012)

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses
por: Yang, Yongping, et al.
Publicado: (2021)

Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces
por: Lee, Myungjin, et al.
Publicado: (2021)

HIV-1 replication activates CD4(+) T cells with specificities for persistent herpes viruses
por: Haas, Anna, et al.
Publicado: (2010)

Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain’s exceptional capacity for sequence variation
por: Brandenberg, Oliver F, et al.
Publicado: (2014)

P09-02. Selection pressure of neutralizing antibodies and viral escape continues in late stages of the disease
por: Rusert, P, et al.
Publicado: (2009)

Reply to correspondence ‘Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a “stochastic” process’ by Gonzalez et al., Retrovirology 2017
por: Oberle, Corinna S., et al.
Publicado: (2017)

Glycosylator: a Python framework for the rapid modeling of glycans
por: Lemmin, Thomas, et al.
Publicado: (2019)

Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies
por: Rusert, Peter, et al.
Publicado: (2011)

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
por: Afroz, Tariq, et al.
Publicado: (2017)

CD4-Specific Designed Ankyrin Repeat Proteins Are Novel Potent HIV Entry Inhibitors with Unique Characteristics
por: Schweizer, Andreas, et al.
Publicado: (2008)

A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology
por: Campbell, Benjamin FN, et al.
Publicado: (2022)

Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV’s Envelope Protein on Viral Replication in Cell Culture
por: Haddox, Hugh K., et al.
Publicado: (2016)

Bacterial vaginosis and adverse outcomes among full-term infants: a cohort study
por: Dingens, Adam S., et al.
Publicado: (2016)

A shifty stop for a hairy tail
por: Olia, Adam S., et al.
Publicado: (2008)

An Exploratory Study of Gender Role Stress and Psychological Distress of Women in Kosovo
por: Kelmendi, Kaltrina, et al.
Publicado: (2022)

Designed ankyrin repeat proteins for detecting prostate-specific antigen expression in vivo
por: Gut, Melanie, et al.
Publicado: (2023)

Three-dimensional structure of a viral genome-delivery portal vertex
por: Olia, Adam S., et al.
Publicado: (2011)

Use of Ionic Liquids and Co-Solvents for Synthesis of Thin-Film Composite Membranes
por: Van den Mooter, Peter-Renaat, et al.
Publicado: (2021)

Massively Parallel Profiling of HIV-1 Resistance to the Fusion Inhibitor Enfuvirtide
por: Dingens, Adam S., et al.
Publicado: (2019)

Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism
por: Deluigi, Mattia, et al.
Publicado: (2021)

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1
por: Ruprecht, Claudia R., et al.
Publicado: (2011)

CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity
por: Ivan, Branislav, et al.
Publicado: (2019)

Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers
por: Weinert, Christopher, et al.
Publicado: (2015)

Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase
por: Lemmin, Thomas, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fpthdbk79rjbicb4qvd6darf1r