Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123

CD123, the alpha chain of the IL-3 receptor, is an attractive target for acute myeloid leukemia (AML) treatment. However, cytotoxic antibodies or T cell engagers targeting CD123 had insufficient efficacy or safety in clinical trials. We show that expression of CD64, the high-affinity receptor for hu...

Descripción completa

Detalles Bibliográficos
Autores principales: Gauthier, Laurent, Virone-Oddos, Angela, Beninga, Jochen, Rossi, Benjamin, Nicolazzi, Céline, Amara, Céline, Blanchard-Alvarez, Audrey, Gourdin, Nicolas, Courta, Jacqueline, Basset, Alexandra, Agnel, Magali, Guillot, Franceline, Grondin, Gwendoline, Bonnevaux, Hélène, Bauchet, Anne-Laure, Morel, Ariane, Morel, Yannis, Chiron, Marielle, Vivier, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497414/
https://www.ncbi.nlm.nih.gov/pubmed/36635380
http://dx.doi.org/10.1038/s41587-022-01626-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497414/
https://www.ncbi.nlm.nih.gov/pubmed/36635380
http://dx.doi.org/10.1038/s41587-022-01626-2

Ejemplares similares