The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure

SUMOylation regulates numerous cellular processes, but what represents the essential functions of this protein modification remains unclear. To address this, we performed genome-scale CRISPR–Cas9-based screens, revealing that the BLM-TOP3A-RMI1-RMI2 (BTRR)-PICH pathway, which resolves ultrafine anap...

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Detalles Bibliográficos
Autores principales: Hertz, Emil P. T., Vega, Ignacio Alonso-de, Kruse, Thomas, Wang, Yiqing, Hendriks, Ivo A., Bizard, Anna H., Eugui-Anta, Ania, Hay, Ronald T., Nielsen, Michael L., Nilsson, Jakob, Hickson, Ian D., Mailand, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497417/
https://www.ncbi.nlm.nih.gov/pubmed/37474739
http://dx.doi.org/10.1038/s41594-023-01045-0

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