Klotho increases antioxidant defenses in astrocytes and ubiquitin–proteasome activity in neurons

Klotho is an antiaging protein, and its levels decline with age and chronic stress. The exogenous administration of Klotho can enhance cognitive performance in mice and negatively modulate the Insulin/IGF1/PI3K/AKT pathway in terms of metabolism. In humans, insulin sensitivity is a hallmark of healt...

Descripción completa

Detalles Bibliográficos
Autores principales: Orellana, Ana Maria, Mazucanti, Caio Henrique, dos Anjos, Leticia Pavan, de Sá Lima, Larissa, Kawamoto, Elisa Mitiko, Scavone, Cristoforo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497516/
https://www.ncbi.nlm.nih.gov/pubmed/37699938
http://dx.doi.org/10.1038/s41598-023-41166-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497516/
https://www.ncbi.nlm.nih.gov/pubmed/37699938
http://dx.doi.org/10.1038/s41598-023-41166-6

Ejemplares similares