Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries

Topologically Associating Domains (TADs) separate vertebrate genomes into insulated regulatory neighborhoods that focus genome-associated processes. TADs are formed by Cohesin-mediated loop extrusion, with many TAD boundaries consisting of clustered binding sites of the CTCF insulator protein. Here...

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Detalles Bibliográficos
Autores principales: Chang, Li-Hsin, Ghosh, Sourav, Papale, Andrea, Luppino, Jennifer M., Miranda, Mélanie, Piras, Vincent, Degrouard, Jéril, Edouard, Joanne, Poncelet, Mallory, Lecouvreur, Nathan, Bloyer, Sébastien, Leforestier, Amélie, Joyce, Eric F., Holcman, David, Noordermeer, Daan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497529/
https://www.ncbi.nlm.nih.gov/pubmed/37699887
http://dx.doi.org/10.1038/s41467-023-41265-y

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