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Amino acid metabolism in health and disease
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorders have been linked with a number of pathological conditions, including metabolic diseases,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497558/ https://www.ncbi.nlm.nih.gov/pubmed/37699892 http://dx.doi.org/10.1038/s41392-023-01569-3 |
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author | Ling, Zhe-Nan Jiang, Yi-Fan Ru, Jun-Nan Lu, Jia-Hua Ding, Bo Wu, Jian |
author_facet | Ling, Zhe-Nan Jiang, Yi-Fan Ru, Jun-Nan Lu, Jia-Hua Ding, Bo Wu, Jian |
author_sort | Ling, Zhe-Nan |
collection | PubMed |
description | Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorders have been linked with a number of pathological conditions, including metabolic diseases, cardiovascular diseases, immune diseases, and cancer. In the case of tumors, alterations in amino acid metabolism can be used not only as clinical indicators of cancer progression but also as therapeutic strategies. Since the growth and development of tumors depend on the intake of foreign amino acids, more and more studies have targeted the metabolism of tumor-related amino acids to selectively kill tumor cells. Furthermore, immune-related studies have confirmed that amino acid metabolism regulates the function of effector T cells and regulatory T cells, affecting the function of immune cells. Therefore, studying amino acid metabolism associated with disease and identifying targets in amino acid metabolic pathways may be helpful for disease treatment. This article mainly focuses on the research of amino acid metabolism in tumor-oriented diseases, and reviews the research and clinical research progress of metabolic diseases, cardiovascular diseases and immune-related diseases related to amino acid metabolism, in order to provide theoretical basis for targeted therapy of amino acid metabolism. |
format | Online Article Text |
id | pubmed-10497558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104975582023-09-14 Amino acid metabolism in health and disease Ling, Zhe-Nan Jiang, Yi-Fan Ru, Jun-Nan Lu, Jia-Hua Ding, Bo Wu, Jian Signal Transduct Target Ther Review Article Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorders have been linked with a number of pathological conditions, including metabolic diseases, cardiovascular diseases, immune diseases, and cancer. In the case of tumors, alterations in amino acid metabolism can be used not only as clinical indicators of cancer progression but also as therapeutic strategies. Since the growth and development of tumors depend on the intake of foreign amino acids, more and more studies have targeted the metabolism of tumor-related amino acids to selectively kill tumor cells. Furthermore, immune-related studies have confirmed that amino acid metabolism regulates the function of effector T cells and regulatory T cells, affecting the function of immune cells. Therefore, studying amino acid metabolism associated with disease and identifying targets in amino acid metabolic pathways may be helpful for disease treatment. This article mainly focuses on the research of amino acid metabolism in tumor-oriented diseases, and reviews the research and clinical research progress of metabolic diseases, cardiovascular diseases and immune-related diseases related to amino acid metabolism, in order to provide theoretical basis for targeted therapy of amino acid metabolism. Nature Publishing Group UK 2023-09-13 /pmc/articles/PMC10497558/ /pubmed/37699892 http://dx.doi.org/10.1038/s41392-023-01569-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Ling, Zhe-Nan Jiang, Yi-Fan Ru, Jun-Nan Lu, Jia-Hua Ding, Bo Wu, Jian Amino acid metabolism in health and disease |
title | Amino acid metabolism in health and disease |
title_full | Amino acid metabolism in health and disease |
title_fullStr | Amino acid metabolism in health and disease |
title_full_unstemmed | Amino acid metabolism in health and disease |
title_short | Amino acid metabolism in health and disease |
title_sort | amino acid metabolism in health and disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497558/ https://www.ncbi.nlm.nih.gov/pubmed/37699892 http://dx.doi.org/10.1038/s41392-023-01569-3 |
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