Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder

Dynamic interactions of neurons and glia in the ventral midbrain mediate reward and addiction behavior. We studied gene expression in 212,713 ventral midbrain single nuclei from 95 individuals with history of opioid misuse, and individuals without drug exposure. Chronic exposure to opioids was not a...

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Detalles Bibliográficos
Autores principales: Wei, Julong, Lambert, Tova Y., Valada, Aditi, Patel, Nikhil, Walker, Kellie, Lenders, Jayna, Schmidt, Carl J., Iskhakova, Marina, Alazizi, Adnan, Mair-Meijers, Henriette, Mash, Deborah C., Luca, Francesca, Pique-Regi, Roger, Bannon, Michael J., Akbarian, Schahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497570/
https://www.ncbi.nlm.nih.gov/pubmed/37699936
http://dx.doi.org/10.1038/s41467-023-41455-8

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