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E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation
The Hippo pathway is a master regulator of organ growth, stem cell renewal, and tumorigenesis, its activation is tightly controlled by various post-translational modifications, including ubiquitination. While several E3 ubiquitin ligases have been identified as regulators of Hippo pathway, the corre...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497580/ https://www.ncbi.nlm.nih.gov/pubmed/37699871 http://dx.doi.org/10.1038/s41419-023-06130-2 |