Cargando…

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort...

Descripción completa

Detalles Bibliográficos
Autores principales: Towns, Clodagh, Richer, Madeleine, Jasaityte, Simona, Stafford, Eleanor J., Joubert, Julie, Antar, Tarek, Martinez-Carrasco, Alejandro, Makarious, Mary B., Casey, Bradford, Vitale, Dan, Levine, Kristin, Leonard, Hampton, Pantazis, Caroline B., Screven, Laurel A., Hernandez, Dena G., Wegel, Claire E., Solle, Justin, Nalls, Mike A., Blauwendraat, Cornelis, Singleton, Andrew B., Tan, Manuela M. X., Iwaki, Hirotaka, Morris, Huw R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497609/
https://www.ncbi.nlm.nih.gov/pubmed/37699923
http://dx.doi.org/10.1038/s41531-023-00533-w
_version_ 1785105341855301632
author Towns, Clodagh
Richer, Madeleine
Jasaityte, Simona
Stafford, Eleanor J.
Joubert, Julie
Antar, Tarek
Martinez-Carrasco, Alejandro
Makarious, Mary B.
Casey, Bradford
Vitale, Dan
Levine, Kristin
Leonard, Hampton
Pantazis, Caroline B.
Screven, Laurel A.
Hernandez, Dena G.
Wegel, Claire E.
Solle, Justin
Nalls, Mike A.
Blauwendraat, Cornelis
Singleton, Andrew B.
Tan, Manuela M. X.
Iwaki, Hirotaka
Morris, Huw R.
author_facet Towns, Clodagh
Richer, Madeleine
Jasaityte, Simona
Stafford, Eleanor J.
Joubert, Julie
Antar, Tarek
Martinez-Carrasco, Alejandro
Makarious, Mary B.
Casey, Bradford
Vitale, Dan
Levine, Kristin
Leonard, Hampton
Pantazis, Caroline B.
Screven, Laurel A.
Hernandez, Dena G.
Wegel, Claire E.
Solle, Justin
Nalls, Mike A.
Blauwendraat, Cornelis
Singleton, Andrew B.
Tan, Manuela M. X.
Iwaki, Hirotaka
Morris, Huw R.
author_sort Towns, Clodagh
collection PubMed
description The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.
format Online
Article
Text
id pubmed-10497609
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-104976092023-09-14 Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2) Towns, Clodagh Richer, Madeleine Jasaityte, Simona Stafford, Eleanor J. Joubert, Julie Antar, Tarek Martinez-Carrasco, Alejandro Makarious, Mary B. Casey, Bradford Vitale, Dan Levine, Kristin Leonard, Hampton Pantazis, Caroline B. Screven, Laurel A. Hernandez, Dena G. Wegel, Claire E. Solle, Justin Nalls, Mike A. Blauwendraat, Cornelis Singleton, Andrew B. Tan, Manuela M. X. Iwaki, Hirotaka Morris, Huw R. NPJ Parkinsons Dis Brief Communication The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia. Nature Publishing Group UK 2023-09-12 /pmc/articles/PMC10497609/ /pubmed/37699923 http://dx.doi.org/10.1038/s41531-023-00533-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Towns, Clodagh
Richer, Madeleine
Jasaityte, Simona
Stafford, Eleanor J.
Joubert, Julie
Antar, Tarek
Martinez-Carrasco, Alejandro
Makarious, Mary B.
Casey, Bradford
Vitale, Dan
Levine, Kristin
Leonard, Hampton
Pantazis, Caroline B.
Screven, Laurel A.
Hernandez, Dena G.
Wegel, Claire E.
Solle, Justin
Nalls, Mike A.
Blauwendraat, Cornelis
Singleton, Andrew B.
Tan, Manuela M. X.
Iwaki, Hirotaka
Morris, Huw R.
Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
title Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
title_full Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
title_fullStr Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
title_full_unstemmed Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
title_short Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
title_sort defining the causes of sporadic parkinson’s disease in the global parkinson’s genetics program (gp2)
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497609/
https://www.ncbi.nlm.nih.gov/pubmed/37699923
http://dx.doi.org/10.1038/s41531-023-00533-w
work_keys_str_mv AT townsclodagh definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT richermadeleine definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT jasaitytesimona definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT staffordeleanorj definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT joubertjulie definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT antartarek definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT martinezcarrascoalejandro definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT makariousmaryb definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT caseybradford definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT vitaledan definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT levinekristin definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT leonardhampton definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT pantaziscarolineb definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT screvenlaurela definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT hernandezdenag definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT wegelclairee definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT sollejustin definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT nallsmikea definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT blauwendraatcornelis definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT singletonandrewb definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT tanmanuelamx definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT iwakihirotaka definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT morrishuwr definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2
AT definingthecausesofsporadicparkinsonsdiseaseintheglobalparkinsonsgeneticsprogramgp2