Bone dysplasia in Hutchinson‐Gilford progeria syndrome is associated with dysregulated differentiation and function of bone cell populations

Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder affecting tissues of mesenchymal origin. Most individuals with HGPS harbor a de novo c.1824C > T (p.G608G) mutation in the gene encoding lamin A (LMNA), which activates a cryptic splice donor site resulting in production of...

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Detalles Bibliográficos
Autores principales: Cabral, Wayne A., Stephan, Chris, Terajima, Masahiko, Thaivalappil, Abhirami A., Blanchard, Owen, Tavarez, Urraca L., Narisu, Narisu, Yan, Tingfen, Wincovitch, Stephen M., Taga, Yuki, Yamauchi, Mitsuo, Kozloff, Kenneth M., Erdos, Michael R., Collins, Francis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497813/
https://www.ncbi.nlm.nih.gov/pubmed/37365004
http://dx.doi.org/10.1111/acel.13903

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