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An association study of cyclase‐associated protein 2 and frailty

Frailty is a geriatric syndrome that results from multisystem impairment caused by age‐associated accumulation of deficits. The frailty index is used to define the level of frailty. Several studies have searched for molecular biomarkers associated with frailty, to meet the needs for personalized car...

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Autores principales: Pelucchi, Silvia, Macchi, Chiara, D'Andrea, Laura, Rossi, Paolo Dionigi, Speciani, Michela Carola, Stringhi, Ramona, Ruscica, Massimiliano, Arosio, Beatrice, Di Luca, Monica, Cesari, Matteo, Edefonti, Valeria, Marcello, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497846/
https://www.ncbi.nlm.nih.gov/pubmed/37537790
http://dx.doi.org/10.1111/acel.13918
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author Pelucchi, Silvia
Macchi, Chiara
D'Andrea, Laura
Rossi, Paolo Dionigi
Speciani, Michela Carola
Stringhi, Ramona
Ruscica, Massimiliano
Arosio, Beatrice
Di Luca, Monica
Cesari, Matteo
Edefonti, Valeria
Marcello, Elena
author_facet Pelucchi, Silvia
Macchi, Chiara
D'Andrea, Laura
Rossi, Paolo Dionigi
Speciani, Michela Carola
Stringhi, Ramona
Ruscica, Massimiliano
Arosio, Beatrice
Di Luca, Monica
Cesari, Matteo
Edefonti, Valeria
Marcello, Elena
author_sort Pelucchi, Silvia
collection PubMed
description Frailty is a geriatric syndrome that results from multisystem impairment caused by age‐associated accumulation of deficits. The frailty index is used to define the level of frailty. Several studies have searched for molecular biomarkers associated with frailty, to meet the needs for personalized care. Cyclase‐associated protein 2 (CAP2) is a multifunctional actin‐binding protein involved in various physiological and pathological processes, that might reflect frailty's intrinsic complexity. This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community‐dwelling older adults (median age: 79; range: 65–92 years) from Milan, Italy. The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1‐unit increase in frailty index leads to ~0.5‐point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., frailty index ≥0.25) than in non‐frail participants. This study shows the association between serum CAP2 concentration and frailty status for the first time, highlighting the potential of CAP2 as a biomarker for age‐associated accumulation of deficits.
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spelling pubmed-104978462023-09-14 An association study of cyclase‐associated protein 2 and frailty Pelucchi, Silvia Macchi, Chiara D'Andrea, Laura Rossi, Paolo Dionigi Speciani, Michela Carola Stringhi, Ramona Ruscica, Massimiliano Arosio, Beatrice Di Luca, Monica Cesari, Matteo Edefonti, Valeria Marcello, Elena Aging Cell Short Communications Frailty is a geriatric syndrome that results from multisystem impairment caused by age‐associated accumulation of deficits. The frailty index is used to define the level of frailty. Several studies have searched for molecular biomarkers associated with frailty, to meet the needs for personalized care. Cyclase‐associated protein 2 (CAP2) is a multifunctional actin‐binding protein involved in various physiological and pathological processes, that might reflect frailty's intrinsic complexity. This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community‐dwelling older adults (median age: 79; range: 65–92 years) from Milan, Italy. The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1‐unit increase in frailty index leads to ~0.5‐point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., frailty index ≥0.25) than in non‐frail participants. This study shows the association between serum CAP2 concentration and frailty status for the first time, highlighting the potential of CAP2 as a biomarker for age‐associated accumulation of deficits. John Wiley and Sons Inc. 2023-08-03 /pmc/articles/PMC10497846/ /pubmed/37537790 http://dx.doi.org/10.1111/acel.13918 Text en © 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Pelucchi, Silvia
Macchi, Chiara
D'Andrea, Laura
Rossi, Paolo Dionigi
Speciani, Michela Carola
Stringhi, Ramona
Ruscica, Massimiliano
Arosio, Beatrice
Di Luca, Monica
Cesari, Matteo
Edefonti, Valeria
Marcello, Elena
An association study of cyclase‐associated protein 2 and frailty
title An association study of cyclase‐associated protein 2 and frailty
title_full An association study of cyclase‐associated protein 2 and frailty
title_fullStr An association study of cyclase‐associated protein 2 and frailty
title_full_unstemmed An association study of cyclase‐associated protein 2 and frailty
title_short An association study of cyclase‐associated protein 2 and frailty
title_sort association study of cyclase‐associated protein 2 and frailty
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497846/
https://www.ncbi.nlm.nih.gov/pubmed/37537790
http://dx.doi.org/10.1111/acel.13918
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