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Chromatin‐transcription interface: The secret of eternal youth?
In their recent study in Nature, Debès et al. report an increase in RNA polymerase II (Pol II)‐mediated transcriptional elongation speed associated with chromatin remodeling during aging in four metazoan animals, two human cell lines, and human blood. Their findings might help us understand why we a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497848/ https://www.ncbi.nlm.nih.gov/pubmed/37427688 http://dx.doi.org/10.1111/acel.13927 |
| _version_ | 1785105392094674944 |
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| author | Izquierdo, José M. |
| author_facet | Izquierdo, José M. |
| author_sort | Izquierdo, José M. |
| collection | PubMed |
| description | In their recent study in Nature, Debès et al. report an increase in RNA polymerase II (Pol II)‐mediated transcriptional elongation speed associated with chromatin remodeling during aging in four metazoan animals, two human cell lines, and human blood. Their findings might help us understand why we age through evolutionarily conserved essential processes, and open a window to the molecular and physiological mechanisms influencing healthspan, lifespan and/or longevity. |
| format | Online Article Text |
| id | pubmed-10497848 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104978482023-09-14 Chromatin‐transcription interface: The secret of eternal youth? Izquierdo, José M. Aging Cell Perspective In their recent study in Nature, Debès et al. report an increase in RNA polymerase II (Pol II)‐mediated transcriptional elongation speed associated with chromatin remodeling during aging in four metazoan animals, two human cell lines, and human blood. Their findings might help us understand why we age through evolutionarily conserved essential processes, and open a window to the molecular and physiological mechanisms influencing healthspan, lifespan and/or longevity. John Wiley and Sons Inc. 2023-07-10 /pmc/articles/PMC10497848/ /pubmed/37427688 http://dx.doi.org/10.1111/acel.13927 Text en © 2023 The Author. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Perspective Izquierdo, José M. Chromatin‐transcription interface: The secret of eternal youth? |
| title | Chromatin‐transcription interface: The secret of eternal youth? |
| title_full | Chromatin‐transcription interface: The secret of eternal youth? |
| title_fullStr | Chromatin‐transcription interface: The secret of eternal youth? |
| title_full_unstemmed | Chromatin‐transcription interface: The secret of eternal youth? |
| title_short | Chromatin‐transcription interface: The secret of eternal youth? |
| title_sort | chromatin‐transcription interface: the secret of eternal youth? |
| topic | Perspective |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497848/ https://www.ncbi.nlm.nih.gov/pubmed/37427688 http://dx.doi.org/10.1111/acel.13927 |
| work_keys_str_mv | AT izquierdojosem chromatintranscriptioninterfacethesecretofeternalyouth |