Decreasing hydrophobicity or shielding hydrophobic areas of CH2 attenuates low pH-induced IgG4 aggregation

Protein aggregation is a major challenge in the development of therapeutic monoclonal antibodies (mAbs). Several stressors can cause protein aggregation, including temperature shifts, mechanical forces, freezing-thawing cycles, oxidants, reductants, and extreme pH. When antibodies are exposed to low...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Qiang, Cao, Chunlai, Wei, Suzhen, He, Hua, Chen, Kangyue, Su, Lijuan, Liu, Qiulian, Li, Shuang, Lai, Yongjie, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497874/
https://www.ncbi.nlm.nih.gov/pubmed/37711444
http://dx.doi.org/10.3389/fbioe.2023.1257665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497874/
https://www.ncbi.nlm.nih.gov/pubmed/37711444
http://dx.doi.org/10.3389/fbioe.2023.1257665

Ejemplares similares