Cargando…

Decreasing hydrophobicity or shielding hydrophobic areas of CH2 attenuates low pH-induced IgG4 aggregation

Protein aggregation is a major challenge in the development of therapeutic monoclonal antibodies (mAbs). Several stressors can cause protein aggregation, including temperature shifts, mechanical forces, freezing-thawing cycles, oxidants, reductants, and extreme pH. When antibodies are exposed to low...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Qiang, Cao, Chunlai, Wei, Suzhen, He, Hua, Chen, Kangyue, Su, Lijuan, Liu, Qiulian, Li, Shuang, Lai, Yongjie, Li, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497874/ https://www.ncbi.nlm.nih.gov/pubmed/37711444 http://dx.doi.org/10.3389/fbioe.2023.1257665

Ejemplares similares

Enzyme Catalyzed Copolymerization of Lignosulfonates for Hydrophobic Coatings
por: Mayr, Sebastian A., et al.
Publicado: (2021)

Challenges and Perspectives in Chemical Synthesis of Highly Hydrophobic Peptides
por: Mueller, Lena K., et al.
Publicado: (2020)

One-Step Purification of Microbially Produced Hydrophobic Terpenes via Process Chromatography
por: Grozdev, Ljubomir, et al.
Publicado: (2019)

Lipid-Based Nanovesicles for Simultaneous Intracellular Delivery of Hydrophobic, Hydrophilic, and Amphiphilic Species
por: Zacheo, Antonella, et al.
Publicado: (2020)

Regulating Protein Corona Formation and Dynamic Protein Exchange by Controlling Nanoparticle Hydrophobicity
por: Yu, Qianhui, et al.
Publicado: (2020)

Functionalization of Bacterial Cellulose Nonwoven by Poly(fluorophenol) to Improve Its Hydrophobicity and Durability
por: Song, Ji Eun, et al.
Publicado: (2019)

Development of fluorescent lateral flow immunoassay for SARS-CoV-2-specific IgM and IgG based on aggregation-induced emission carbon dots
por: Ju, Jian, et al.
Publicado: (2022)

Mild Fractionation of Hydrophilic and Hydrophobic Components From Neochloris oleoabundans Using Ionic Liquids
por: Desai, Rupali K., et al.
Publicado: (2019)

Methane Emission Reduction and Biological Characteristics of Landfill Cover Soil Amended With Hydrophobic Biochar
por: Qin, Yongli, et al.
Publicado: (2022)

Purification of a Hydrophobic Elastin-Like Protein Toward Scale-Suitable Production of Biomaterials
por: Haas, Sandra, et al.
Publicado: (2022)

Effect of Membrane Hydrophobicity and Thickness on Energy-Efficient Dissolved Oxygen Removal From Algal Culture
por: Kishi, Masatoshi, et al.
Publicado: (2020)

Using Carboxymethyl Cellulose as the Additive With Enzyme-Catalyzed Carboxylated Starch to Prepare the Film With Enhanced Mechanical and Hydrophobic Properties
por: Liu, Can, et al.
Publicado: (2021)

Ensembles of Hydrophobicity Scales as Potent Classifiers for Chimeric Virus-Like Particle Solubility – An Amino Acid Sequence-Based Machine Learning Approach
por: Vormittag, Philipp, et al.
Publicado: (2020)

The Maximal Pore Size of Hydrophobic Microporous Membranes Does Not Fully Characterize the Resistance to Plasma Breakthrough of Membrane Devices for Extracorporeal Blood Oxygenation
por: Fragomeni, Gionata, et al.
Publicado: (2020)

Expression Profiling and Glycan Engineering of IgG Subclass 1–4 in Nicotiana benthamiana
por: Kallolimath, Somanath, et al.
Publicado: (2020)

Synthesis of Hydrophobic Propionyl Neohesperidin Ester Using an Immobilied Enzyme and Description of Its Anti-proliferative and Pro-apoptotic Effects on MCF-7 Human Breast Cancer Cells
por: Xia, Na, et al.
Publicado: (2020)

A simple and efficient strategy for trace detection of ferroptosis-related miRNAs based on novel hydrophobic paper-based plasmonic substrate and “inverse molecular sentinel (iMS)” nanoprobes
por: Wang, Youwei, et al.
Publicado: (2023)

Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions
por: Coghlan, Jill, et al.
Publicado: (2022)

Streamlining the Transition From Yeast Surface Display of Antibody Fragment Immune Libraries to the Production as IgG Format in Mammalian Cells
por: Fiebig, David, et al.
Publicado: (2022)

Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS(3): The Effects of Bioprocessing Conditions on Productivity and Product Quality
por: Strasser, Lisa, et al.
Publicado: (2021)

Expanding the pH range of glutamate decarboxylase from L. pltarum LC84 by site-directed mutagenesis
por: Yang, Lijuan, et al.
Publicado: (2023)

Real-time monitoring of hydrophobic aggregation reveals a critical role of cooperativity in hydrophobic effect
por: Jiang, Liguo, et al.
Publicado: (2017)

Enabling the complete valorization of hybrid Pennisetum: Directly using alkaline black liquor for preparing UV-shielding biodegradable films
por: Qian, Haojiang, et al.
Publicado: (2022)

A local-saturation-and-delay MRI method for evaluation of red blood cells aggregation in vivo for tumor-bearing or drug-used rats
por: Shan, Haiwei, et al.
Publicado: (2023)

EMI Shielding of the Hydrophobic, Flexible, Lightweight Carbonless Nano-Plate Composites
por: Raagulan, Kanthasamy, et al.
Publicado: (2020)

An engineered human IgG1 CH2 domain with decreased aggregation and nonspecific binding
por: Cao, Guangcan, et al.
Publicado: (2019)

Synthesis and Photothermal Effects of Intracellular Aggregating Nanodrugs Targeting Nasopharyngeal Carcinoma
por: Zhong, Ying, et al.
Publicado: (2021)

Protein Unfolding and Aggregation near a Hydrophobic Interface
por: March, David, et al.
Publicado: (2021)

Application of the pH-Responsive PCL/PEG-Nar Nanofiber Membrane in the Treatment of Osteoarthritis
por: Wang, Zetao, et al.
Publicado: (2022)

Impact of nanocarrier aggregation on EPR-mediated tumor targeting
por: Surya Teja, S. P., et al.
Publicado: (2023)

EMI Shielding Nanocomposite Laminates with High Temperature Resistance, Hydrophobicity and Anticorrosion Properties
por: Wu, Shaojun, et al.
Publicado: (2021)

Cryopreservation of Human iPS Cell Aggregates in a DMSO-Free Solution—An Optimization and Comparative Study
por: Li, Rui, et al.
Publicado: (2020)

Amyloid-Like Aggregation in Diseases and Biomaterials: Osmosis of Structural Information
por: Balasco, Nicole, et al.
Publicado: (2021)

Immobilization and Purification of Enzymes With the Novel Affinity Tag ChBD-AB From Chitinolyticbacter meiyuanensis SYBC-H1
por: Zhou, Jie, et al.
Publicado: (2020)

Fucoidan-Mediated Anisotropic Calcium Carbonate Nanorods of pH-Responsive Drug Release for Antitumor Therapy
por: Wang, Pei, et al.
Publicado: (2022)

The Feasibility of Targeted Magnetic Iron Oxide Nanoagent for Noninvasive IgA Nephropathy Diagnosis
por: Wu, Yaoyao, et al.
Publicado: (2021)

Electrospun Nanofibers With pH-Responsive Coatings for Control of Release Kinetics
por: Sayin, Sezin, et al.
Publicado: (2019)

A fresh pH-responsive imipenem-loaded nanocarrier against Acinetobacter baumannii with a synergetic effect
por: Gui, Shumin, et al.
Publicado: (2023)

An Assay to Evaluate the Function of Liposomal Platelet Substitutes Delivered to Platelet Aggregates
por: Tan, Suyun Janet, et al.
Publicado: (2019)

A mechanistic model of cross-bridge migration in RBC aggregation and disaggregation
por: Maung Ye, Swe Soe, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_19t5vf5oq9damm2ek4ce1b5oar