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Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents
Normally, the host immunological response to viral infection is coordinated to restore homeostasis and protect the individual from possible tissue damage. The two major approaches are adopted by the host to deal with the pathogen: resistance or tolerance. The nature of the responses often differs be...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497949/ https://www.ncbi.nlm.nih.gov/pubmed/37711609 http://dx.doi.org/10.3389/fimmu.2023.1239572 |
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author | Pereira, Patrick Douglas Corrêa Diniz, Daniel Guerreiro da Costa, Emanuel Ramos Magalhães, Nara Gyzely de Morais da Silva, Anderson de Jesus Falcão Leite, Jéssica Gizele Sousa Almeida, Natan Ibraim Pires Cunha, Kelle de Nazaré de Melo, Mauro André Damasceno Vasconcelos, Pedro Fernando da Costa Diniz, José Antonio Picanço Brites, Dora Anthony, Daniel Clive Diniz, Cristovam Wanderley Picanço Guerreiro-Diniz, Cristovam |
author_facet | Pereira, Patrick Douglas Corrêa Diniz, Daniel Guerreiro da Costa, Emanuel Ramos Magalhães, Nara Gyzely de Morais da Silva, Anderson de Jesus Falcão Leite, Jéssica Gizele Sousa Almeida, Natan Ibraim Pires Cunha, Kelle de Nazaré de Melo, Mauro André Damasceno Vasconcelos, Pedro Fernando da Costa Diniz, José Antonio Picanço Brites, Dora Anthony, Daniel Clive Diniz, Cristovam Wanderley Picanço Guerreiro-Diniz, Cristovam |
author_sort | Pereira, Patrick Douglas Corrêa |
collection | PubMed |
description | Normally, the host immunological response to viral infection is coordinated to restore homeostasis and protect the individual from possible tissue damage. The two major approaches are adopted by the host to deal with the pathogen: resistance or tolerance. The nature of the responses often differs between species and between individuals of the same species. Resistance includes innate and adaptive immune responses to control virus replication. Disease tolerance relies on the immune response allowing the coexistence of infections in the host with minimal or no clinical signs, while maintaining sufficient viral replication for transmission. Here, we compared the virome of bats, rodents and migratory birds and the molecular mechanisms underlying symptomatic and asymptomatic disease progression. We also explore the influence of the host physiology and environmental influences on RNA virus expression and how it impacts on the whole brain transcriptome of seemingly healthy semipalmated sandpiper (Calidris pusilla) and spotted sandpiper (Actitis macularius). Three time points throughout the year were selected to understand the importance of longitudinal surveys in the characterization of the virome. We finally revisited evidence that upstream and downstream regulation of the inflammatory response is, respectively, associated with resistance and tolerance to viral infections. |
format | Online Article Text |
id | pubmed-10497949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104979492023-09-14 Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents Pereira, Patrick Douglas Corrêa Diniz, Daniel Guerreiro da Costa, Emanuel Ramos Magalhães, Nara Gyzely de Morais da Silva, Anderson de Jesus Falcão Leite, Jéssica Gizele Sousa Almeida, Natan Ibraim Pires Cunha, Kelle de Nazaré de Melo, Mauro André Damasceno Vasconcelos, Pedro Fernando da Costa Diniz, José Antonio Picanço Brites, Dora Anthony, Daniel Clive Diniz, Cristovam Wanderley Picanço Guerreiro-Diniz, Cristovam Front Immunol Immunology Normally, the host immunological response to viral infection is coordinated to restore homeostasis and protect the individual from possible tissue damage. The two major approaches are adopted by the host to deal with the pathogen: resistance or tolerance. The nature of the responses often differs between species and between individuals of the same species. Resistance includes innate and adaptive immune responses to control virus replication. Disease tolerance relies on the immune response allowing the coexistence of infections in the host with minimal or no clinical signs, while maintaining sufficient viral replication for transmission. Here, we compared the virome of bats, rodents and migratory birds and the molecular mechanisms underlying symptomatic and asymptomatic disease progression. We also explore the influence of the host physiology and environmental influences on RNA virus expression and how it impacts on the whole brain transcriptome of seemingly healthy semipalmated sandpiper (Calidris pusilla) and spotted sandpiper (Actitis macularius). Three time points throughout the year were selected to understand the importance of longitudinal surveys in the characterization of the virome. We finally revisited evidence that upstream and downstream regulation of the inflammatory response is, respectively, associated with resistance and tolerance to viral infections. Frontiers Media S.A. 2023-08-29 /pmc/articles/PMC10497949/ /pubmed/37711609 http://dx.doi.org/10.3389/fimmu.2023.1239572 Text en Copyright © 2023 Pereira, Diniz, da Costa, Magalhães, da Silva, Leite, Almeida, Cunha, de Melo, Vasconcelos, Diniz, Brites, Anthony, Diniz and Guerreiro-Diniz https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Pereira, Patrick Douglas Corrêa Diniz, Daniel Guerreiro da Costa, Emanuel Ramos Magalhães, Nara Gyzely de Morais da Silva, Anderson de Jesus Falcão Leite, Jéssica Gizele Sousa Almeida, Natan Ibraim Pires Cunha, Kelle de Nazaré de Melo, Mauro André Damasceno Vasconcelos, Pedro Fernando da Costa Diniz, José Antonio Picanço Brites, Dora Anthony, Daniel Clive Diniz, Cristovam Wanderley Picanço Guerreiro-Diniz, Cristovam Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents |
title | Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents |
title_full | Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents |
title_fullStr | Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents |
title_full_unstemmed | Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents |
title_short | Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents |
title_sort | genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497949/ https://www.ncbi.nlm.nih.gov/pubmed/37711609 http://dx.doi.org/10.3389/fimmu.2023.1239572 |
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