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Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys

OBJECTIVE: Anxious behaviors often occur in individuals who have experienced early adversity. Anxious behaviors can bring many hazards, such as social withdrawal, eating disorders, negative self‐efficacy, self‐injurious thoughts and behaviors, anxiety disorders, and even depression. Abnormal behavio...

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Autores principales: Feng, Xiao‐Li, Wang, Jiao‐Jian, Wu, Jing, Ren, Xiao‐Feng, Zhou, Hui, Li, Si‐Yu, Zhang, Jie, Wang, Sheng‐Hai, Wang, Yun, Hu, Zheng‐Fei, Hu, Xin‐Tian, Jiang, Tian‐Zi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498070/
https://www.ncbi.nlm.nih.gov/pubmed/37464725
http://dx.doi.org/10.1002/brb3.3027
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author Feng, Xiao‐Li
Wang, Jiao‐Jian
Wu, Jing
Ren, Xiao‐Feng
Zhou, Hui
Li, Si‐Yu
Zhang, Jie
Wang, Sheng‐Hai
Wang, Yun
Hu, Zheng‐Fei
Hu, Xin‐Tian
Jiang, Tian‐Zi
author_facet Feng, Xiao‐Li
Wang, Jiao‐Jian
Wu, Jing
Ren, Xiao‐Feng
Zhou, Hui
Li, Si‐Yu
Zhang, Jie
Wang, Sheng‐Hai
Wang, Yun
Hu, Zheng‐Fei
Hu, Xin‐Tian
Jiang, Tian‐Zi
author_sort Feng, Xiao‐Li
collection PubMed
description OBJECTIVE: Anxious behaviors often occur in individuals who have experienced early adversity. Anxious behaviors can bring many hazards, such as social withdrawal, eating disorders, negative self‐efficacy, self‐injurious thoughts and behaviors, anxiety disorders, and even depression. Abnormal behavior are is closely related to changes in corresponding circuit functions in the brain. This study investigated the relationship between brain circuits and anxious behaviors in maternal‐deprived rhesus monkey animal model, which mimic early adversity in human. METHODS: Twenty‐five rhesus monkeys (Macaca mulatta) were grouped by two different rearing conditions: 11 normal control and mother‐reared (MR) monkeys and 14 maternally deprived and peer‐reared (MD) monkeys. After obtaining images of the brain areas with significant differences in maternal separation and normal control macaque function, the relationship between functional junction intensity and stereotypical behaviors was determined by correlation analysis. RESULTS: The correlation analysis revealed that stereotypical behaviors were negatively correlated with the coupling between the left lateral amygdala subregion and the left inferior frontal gyrus in both MD and MR macaques. CONCLUSION: This study suggests that early adversity‐induced anxious behaviors are associated with changes in the strength of the amygdala–prefrontal connection. The normalization of the regions involved in the functional connection might reverse the behavioral abnormality. It provides a solid foundation for effective intervention in human early adversity. SIGNIFICANCE STATEMENT: This study suggests that early adversity‐induced anxious behaviors are associated with changes in the strength of the amygdala–prefrontal connection. The higher the amygdala–prefrontal connection strength, the less stereotyped behaviors exhibited by monkeys experiencing early adversity. Thus, in the future, changing the strength of the amygdala–prefrontal connection may reverse the behavioral abnormalities of individuals who experience early adversity. This study provides a solid foundation for effective intervention in humans' early adversity.
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spelling pubmed-104980702023-09-14 Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys Feng, Xiao‐Li Wang, Jiao‐Jian Wu, Jing Ren, Xiao‐Feng Zhou, Hui Li, Si‐Yu Zhang, Jie Wang, Sheng‐Hai Wang, Yun Hu, Zheng‐Fei Hu, Xin‐Tian Jiang, Tian‐Zi Brain Behav Original Articles OBJECTIVE: Anxious behaviors often occur in individuals who have experienced early adversity. Anxious behaviors can bring many hazards, such as social withdrawal, eating disorders, negative self‐efficacy, self‐injurious thoughts and behaviors, anxiety disorders, and even depression. Abnormal behavior are is closely related to changes in corresponding circuit functions in the brain. This study investigated the relationship between brain circuits and anxious behaviors in maternal‐deprived rhesus monkey animal model, which mimic early adversity in human. METHODS: Twenty‐five rhesus monkeys (Macaca mulatta) were grouped by two different rearing conditions: 11 normal control and mother‐reared (MR) monkeys and 14 maternally deprived and peer‐reared (MD) monkeys. After obtaining images of the brain areas with significant differences in maternal separation and normal control macaque function, the relationship between functional junction intensity and stereotypical behaviors was determined by correlation analysis. RESULTS: The correlation analysis revealed that stereotypical behaviors were negatively correlated with the coupling between the left lateral amygdala subregion and the left inferior frontal gyrus in both MD and MR macaques. CONCLUSION: This study suggests that early adversity‐induced anxious behaviors are associated with changes in the strength of the amygdala–prefrontal connection. The normalization of the regions involved in the functional connection might reverse the behavioral abnormality. It provides a solid foundation for effective intervention in human early adversity. SIGNIFICANCE STATEMENT: This study suggests that early adversity‐induced anxious behaviors are associated with changes in the strength of the amygdala–prefrontal connection. The higher the amygdala–prefrontal connection strength, the less stereotyped behaviors exhibited by monkeys experiencing early adversity. Thus, in the future, changing the strength of the amygdala–prefrontal connection may reverse the behavioral abnormalities of individuals who experience early adversity. This study provides a solid foundation for effective intervention in humans' early adversity. John Wiley and Sons Inc. 2023-07-18 /pmc/articles/PMC10498070/ /pubmed/37464725 http://dx.doi.org/10.1002/brb3.3027 Text en © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Feng, Xiao‐Li
Wang, Jiao‐Jian
Wu, Jing
Ren, Xiao‐Feng
Zhou, Hui
Li, Si‐Yu
Zhang, Jie
Wang, Sheng‐Hai
Wang, Yun
Hu, Zheng‐Fei
Hu, Xin‐Tian
Jiang, Tian‐Zi
Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys
title Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys
title_full Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys
title_fullStr Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys
title_full_unstemmed Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys
title_short Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys
title_sort abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498070/
https://www.ncbi.nlm.nih.gov/pubmed/37464725
http://dx.doi.org/10.1002/brb3.3027
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