Cargando…

Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system

The cavitation dynamics of a two-bubble system in viscoelastic media excited by dual-frequency ultrasound is studied numerically with a focus on the effects of inter-bubble interactions. Compared to the isolated bubble cases, the enhancement or suppression effects can be exerted on the amplitude and...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Dui, Yang, Qianru, Lei, Shuang, Fu, Jia, Ji, Xiaojuan, Wang, Xiuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498094/
https://www.ncbi.nlm.nih.gov/pubmed/37688945
http://dx.doi.org/10.1016/j.ultsonch.2023.106586
_version_ 1785105445977849856
author Qin, Dui
Yang, Qianru
Lei, Shuang
Fu, Jia
Ji, Xiaojuan
Wang, Xiuxin
author_facet Qin, Dui
Yang, Qianru
Lei, Shuang
Fu, Jia
Ji, Xiaojuan
Wang, Xiuxin
author_sort Qin, Dui
collection PubMed
description The cavitation dynamics of a two-bubble system in viscoelastic media excited by dual-frequency ultrasound is studied numerically with a focus on the effects of inter-bubble interactions. Compared to the isolated bubble cases, the enhancement or suppression effects can be exerted on the amplitude and nonlinearity of the bubble oscillations to different degrees. Moreover, the interaction effects are found to be highly sensitive to multiple paramount parameters related to the two-bubble system, the dual-frequency ultrasound and the medium viscoelasticity. Specifically, the larger bubble of a two-bubble system shows a stronger effect on the smaller one, and this effect becomes more pronounced when the larger bubble undergoes harmonic and/or subharmonic resonances as well as the two bubbles get closer (e.g., d(0) < 100 μm). For the influences of the dual-frequency excitation, the results show that the bubbles can achieve enhanced harmonic and/or subharmonic oscillations as the frequency combinations with small frequency differences (e.g., Δf < 0.2 MHz) close to the corresponding resonance frequencies of bubbles, and the interaction effects are consequently intensified. Similarly, the bubble oscillations and the interaction effects can also be enhanced as the acoustic pressure amplitude of each frequency component is equal and the pressure amplitude p(A) increases. Above a pressure threshold (p(A) = 215 kPa), a larger bubble undergoes period 2 (P2) oscillations, which can force a smaller bubble to change its oscillation pattern from period 1 (P1) into P2 oscillations. In addition, it is found that the medium viscosity dampens the bubble oscillations while the medium elasticity affects the bubble resonances, accordingly exhibiting stronger interaction effects at smaller viscosities (e.g., μ < 4 mPa·s) or certain elasticities (approximately G = 70–120 kPa, G = 160–200 kPa and G = 640–780 kPa) at which the bubble resonances occur. The study can contribute to a better understanding of the complex dynamic behaviors of interacting cavitation bubbles in viscoelastic tissues for high efficient cavitation-mediated biomedical applications using dual-frequency ultrasound.
format Online
Article
Text
id pubmed-10498094
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-104980942023-09-14 Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system Qin, Dui Yang, Qianru Lei, Shuang Fu, Jia Ji, Xiaojuan Wang, Xiuxin Ultrason Sonochem Original Research Article The cavitation dynamics of a two-bubble system in viscoelastic media excited by dual-frequency ultrasound is studied numerically with a focus on the effects of inter-bubble interactions. Compared to the isolated bubble cases, the enhancement or suppression effects can be exerted on the amplitude and nonlinearity of the bubble oscillations to different degrees. Moreover, the interaction effects are found to be highly sensitive to multiple paramount parameters related to the two-bubble system, the dual-frequency ultrasound and the medium viscoelasticity. Specifically, the larger bubble of a two-bubble system shows a stronger effect on the smaller one, and this effect becomes more pronounced when the larger bubble undergoes harmonic and/or subharmonic resonances as well as the two bubbles get closer (e.g., d(0) < 100 μm). For the influences of the dual-frequency excitation, the results show that the bubbles can achieve enhanced harmonic and/or subharmonic oscillations as the frequency combinations with small frequency differences (e.g., Δf < 0.2 MHz) close to the corresponding resonance frequencies of bubbles, and the interaction effects are consequently intensified. Similarly, the bubble oscillations and the interaction effects can also be enhanced as the acoustic pressure amplitude of each frequency component is equal and the pressure amplitude p(A) increases. Above a pressure threshold (p(A) = 215 kPa), a larger bubble undergoes period 2 (P2) oscillations, which can force a smaller bubble to change its oscillation pattern from period 1 (P1) into P2 oscillations. In addition, it is found that the medium viscosity dampens the bubble oscillations while the medium elasticity affects the bubble resonances, accordingly exhibiting stronger interaction effects at smaller viscosities (e.g., μ < 4 mPa·s) or certain elasticities (approximately G = 70–120 kPa, G = 160–200 kPa and G = 640–780 kPa) at which the bubble resonances occur. The study can contribute to a better understanding of the complex dynamic behaviors of interacting cavitation bubbles in viscoelastic tissues for high efficient cavitation-mediated biomedical applications using dual-frequency ultrasound. Elsevier 2023-09-04 /pmc/articles/PMC10498094/ /pubmed/37688945 http://dx.doi.org/10.1016/j.ultsonch.2023.106586 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Qin, Dui
Yang, Qianru
Lei, Shuang
Fu, Jia
Ji, Xiaojuan
Wang, Xiuxin
Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system
title Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system
title_full Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system
title_fullStr Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system
title_full_unstemmed Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system
title_short Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system
title_sort investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498094/
https://www.ncbi.nlm.nih.gov/pubmed/37688945
http://dx.doi.org/10.1016/j.ultsonch.2023.106586
work_keys_str_mv AT qindui investigationofinteractioneffectsondualfrequencydrivencavitationdynamicsinatwobubblesystem
AT yangqianru investigationofinteractioneffectsondualfrequencydrivencavitationdynamicsinatwobubblesystem
AT leishuang investigationofinteractioneffectsondualfrequencydrivencavitationdynamicsinatwobubblesystem
AT fujia investigationofinteractioneffectsondualfrequencydrivencavitationdynamicsinatwobubblesystem
AT jixiaojuan investigationofinteractioneffectsondualfrequencydrivencavitationdynamicsinatwobubblesystem
AT wangxiuxin investigationofinteractioneffectsondualfrequencydrivencavitationdynamicsinatwobubblesystem