A case of false positive opiate immunoassay results from rifampin (rifampicin) treatment

The drug screen test on a 12-year-old male patient was positive for opiates by a kinetic interaction of microparticles in solution (KIMS) immunoassay method on the Roche Cobas C502. The positive opiates result was not confirmed by the liquid chromatography-tandem mass spectrometry (LC-MS/MS) method....

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Detalles Bibliográficos
Autores principales: Lam, K.H. Brian, Song, Lu, Buggs, Vincent, Vithlani, Gopal, Metushi, Imir G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498289/
https://www.ncbi.nlm.nih.gov/pubmed/37711668
http://dx.doi.org/10.1016/j.plabm.2023.e00334
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author Lam, K.H. Brian
Song, Lu
Buggs, Vincent
Vithlani, Gopal
Metushi, Imir G.
author_facet Lam, K.H. Brian
Song, Lu
Buggs, Vincent
Vithlani, Gopal
Metushi, Imir G.
author_sort Lam, K.H. Brian
collection PubMed
description The drug screen test on a 12-year-old male patient was positive for opiates by a kinetic interaction of microparticles in solution (KIMS) immunoassay method on the Roche Cobas C502. The positive opiates result was not confirmed by the liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. A chart review revealed that the patient had tuberculosis and was on rifampin. We spiked rifampin into drug-free urine and tested opiates with the Cobas method. Once again, a positive result was obtained. This case showed that rifampin can still cause false positive opiate results measured with the KIMS method. We want to stress the importance of confirming positive screen results by more specific methods such as LC-MS/MS.
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spelling pubmed-104982892023-09-14 A case of false positive opiate immunoassay results from rifampin (rifampicin) treatment Lam, K.H. Brian Song, Lu Buggs, Vincent Vithlani, Gopal Metushi, Imir G. Pract Lab Med Case Report The drug screen test on a 12-year-old male patient was positive for opiates by a kinetic interaction of microparticles in solution (KIMS) immunoassay method on the Roche Cobas C502. The positive opiates result was not confirmed by the liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. A chart review revealed that the patient had tuberculosis and was on rifampin. We spiked rifampin into drug-free urine and tested opiates with the Cobas method. Once again, a positive result was obtained. This case showed that rifampin can still cause false positive opiate results measured with the KIMS method. We want to stress the importance of confirming positive screen results by more specific methods such as LC-MS/MS. Elsevier 2023-08-29 /pmc/articles/PMC10498289/ /pubmed/37711668 http://dx.doi.org/10.1016/j.plabm.2023.e00334 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Lam, K.H. Brian
Song, Lu
Buggs, Vincent
Vithlani, Gopal
Metushi, Imir G.
A case of false positive opiate immunoassay results from rifampin (rifampicin) treatment
title A case of false positive opiate immunoassay results from rifampin (rifampicin) treatment
title_full A case of false positive opiate immunoassay results from rifampin (rifampicin) treatment
title_fullStr A case of false positive opiate immunoassay results from rifampin (rifampicin) treatment
title_full_unstemmed A case of false positive opiate immunoassay results from rifampin (rifampicin) treatment
title_short A case of false positive opiate immunoassay results from rifampin (rifampicin) treatment
title_sort case of false positive opiate immunoassay results from rifampin (rifampicin) treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498289/
https://www.ncbi.nlm.nih.gov/pubmed/37711668
http://dx.doi.org/10.1016/j.plabm.2023.e00334
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