Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage

Increasing evidence shows that metabolic factors are involved in the pathological process of osteoarthritis (OA). Lactate has been shown to contribute to the onset and progression of diseases. While whether lactate is involved in the pathogenesis of OA through impaired chondrocyte function and its m...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yi-Fan, Wang, Guan, Ding, Lu, Bai, Zi-Ran, Leng, Yi, Tian, Jun-Wei, Zhang, Jian-Zeng, Li, Yan-Qi, Ahmad, Qin, Yuan-Hua, Li, Xia, Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498433/
https://www.ncbi.nlm.nih.gov/pubmed/37688977
http://dx.doi.org/10.1016/j.redox.2023.102867

Ejemplares similares

Ejemplares similares