Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation

The mechanistic target of the rapamycin (mTOR) pathway, which participates in the regulation of cellular growth and metabolism, is aberrantly regulated in various cancer types. The mTOR complex 2 (mTORC2), which consists of the core components mTOR, Rictor, mSin1, and mLST8, primarily responds to gr...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yingji, Jiao, Dongyue, He, Huiying, Sun, Huiru, Liu, Yajuan, Shi, Qing, Zhang, Pingzhao, Li, Yao, Mo, Ren, Gao, Kun, Wang, Chenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498434/
https://www.ncbi.nlm.nih.gov/pubmed/37688978
http://dx.doi.org/10.1016/j.redox.2023.102872

Ejemplares similares

Ejemplares similares