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Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese

OBJECTIVE: As our society grows older, both bone loss and fatty liver have become important issues. However, the relationship between reduced bone mineral density and fatty liver remains controversial. The purpose of this study was to investigate the relationship between nonalcoholic fatty liver dis...

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Autores principales: Zhang, Guangheng, Zhao, Yingsong, Wang, Siyuan, Gong, Qing, Li, Hewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498582/
https://www.ncbi.nlm.nih.gov/pubmed/37705028
http://dx.doi.org/10.1186/s13018-023-04168-8
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author Zhang, Guangheng
Zhao, Yingsong
Wang, Siyuan
Gong, Qing
Li, Hewei
author_facet Zhang, Guangheng
Zhao, Yingsong
Wang, Siyuan
Gong, Qing
Li, Hewei
author_sort Zhang, Guangheng
collection PubMed
description OBJECTIVE: As our society grows older, both bone loss and fatty liver have become important issues. However, the relationship between reduced bone mineral density and fatty liver remains controversial. The purpose of this study was to investigate the relationship between nonalcoholic fatty liver disease and less bone mineral density in the ankles of Chinese people over 65. METHODS: The research included 716 older adults over the age of 65 who underwent a comprehensive health screening. A logistic regression model was used to investigate the relationship between nonalcoholic fatty liver disease (NAFLD) and ankle bone mineral density. RESULTS: A logistic regression model was used to analyze the odds ratios of reduced bone mineral density between patients with fatty liver and controls. In the adjusted model, adjustments were made for age, sex, systolic blood pressure, diastolic blood pressure, overweight rate, history of hypertension, history of diabetes, history of smoking, history of alcohol consumption, fasting glucose, hemoglobin, urea, creatinine, triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, waist circumference, total protein, albumin, and globulin. The adjusted OR (aOR) for reduced bone mineral density was 0.66 [95% confidence interval (CI) = 0.45–0.97, P = 0.034 < 0.05]. In subgroup analysis by age, sex, and BMI, women, age > 75 years, and BIM < 25 were statistically significant. CONCLUSION: This study suggested that NAFLD is associated with a reduced risk of reduced heel bone mass. More research needs to be done to back up the results of this study and look into possible problems.
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spelling pubmed-104985822023-09-14 Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese Zhang, Guangheng Zhao, Yingsong Wang, Siyuan Gong, Qing Li, Hewei J Orthop Surg Res Research Article OBJECTIVE: As our society grows older, both bone loss and fatty liver have become important issues. However, the relationship between reduced bone mineral density and fatty liver remains controversial. The purpose of this study was to investigate the relationship between nonalcoholic fatty liver disease and less bone mineral density in the ankles of Chinese people over 65. METHODS: The research included 716 older adults over the age of 65 who underwent a comprehensive health screening. A logistic regression model was used to investigate the relationship between nonalcoholic fatty liver disease (NAFLD) and ankle bone mineral density. RESULTS: A logistic regression model was used to analyze the odds ratios of reduced bone mineral density between patients with fatty liver and controls. In the adjusted model, adjustments were made for age, sex, systolic blood pressure, diastolic blood pressure, overweight rate, history of hypertension, history of diabetes, history of smoking, history of alcohol consumption, fasting glucose, hemoglobin, urea, creatinine, triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, waist circumference, total protein, albumin, and globulin. The adjusted OR (aOR) for reduced bone mineral density was 0.66 [95% confidence interval (CI) = 0.45–0.97, P = 0.034 < 0.05]. In subgroup analysis by age, sex, and BMI, women, age > 75 years, and BIM < 25 were statistically significant. CONCLUSION: This study suggested that NAFLD is associated with a reduced risk of reduced heel bone mass. More research needs to be done to back up the results of this study and look into possible problems. BioMed Central 2023-09-13 /pmc/articles/PMC10498582/ /pubmed/37705028 http://dx.doi.org/10.1186/s13018-023-04168-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zhang, Guangheng
Zhao, Yingsong
Wang, Siyuan
Gong, Qing
Li, Hewei
Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese
title Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese
title_full Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese
title_fullStr Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese
title_full_unstemmed Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese
title_short Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese
title_sort relationship between nonalcoholic fatty liver disease and bone mineral density in elderly chinese
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498582/
https://www.ncbi.nlm.nih.gov/pubmed/37705028
http://dx.doi.org/10.1186/s13018-023-04168-8
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