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A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1(G93A) model of ALS

BACKGROUND: Numerous genes, including SOD1, mutated in familial and sporadic amyotrophic lateral sclerosis (f/sALS) share a role in DNA damage and repair, emphasizing genome disintegration in ALS. One possible outcome of chromosomal instability and repair processes is extrachromosomal circular DNA (...

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Detalles Bibliográficos
Autores principales:	Gerovska, Daniela, Noer, Julie B., Qin, Yating, Ain, Quratul, Januzi, Donjetë, Schwab, Matthias, Witte, Otto W., Araúzo-Bravo, Marcos J., Kretz, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498603/ https://www.ncbi.nlm.nih.gov/pubmed/37705092 http://dx.doi.org/10.1186/s13578-023-01116-1

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