A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease

Ferroptosis, an iron-dependent cell death, plays a crucial role in the pathology of Alzheimer's disease (AD). Several characteristics of AD, including excessive iron accumulation, elevated lipid peroxide and reactive oxygen species (ROS) levels, and decreased glutathione peroxidase 4 (GPX4) lev...

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Detalles Bibliográficos
Autores principales: Baruah, Prayasee, Moorthy, Hariharan, Ramesh, Madhu, Padhi, Dikshaa, Govindaraju, Thimmaiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498722/
https://www.ncbi.nlm.nih.gov/pubmed/37712018
http://dx.doi.org/10.1039/d3sc02350h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498722/
https://www.ncbi.nlm.nih.gov/pubmed/37712018
http://dx.doi.org/10.1039/d3sc02350h

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