Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid

In obesity, adipose tissue infiltrating macrophages acquire a unique pro-inflammatory polarization, thereby playing a key role in the development of chronic inflammation and Type 2 diabetes. Increased saturated fatty acids (SFAs) levels have been proposed to drive this specific polarization. Accordi...

Descripción completa

Detalles Bibliográficos
Autores principales: Iovino, Margaud, Colonval, Megan, Wilkin, Chloé, L’homme, Laurent, Lassence, Cédric, Campas, Manon, Peulen, Olivier, de Tullio, Pascal, Piette, Jacques, Legrand-Poels, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498766/
https://www.ncbi.nlm.nih.gov/pubmed/37711626
http://dx.doi.org/10.3389/fimmu.2023.1204126

Ejemplares similares

Ejemplares similares