Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders

Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals. Here we report the discovery and characterization of first-in-class, humanized PRL neutralizing monoclonal antibodies (PRL mAbs). We obtained two pot...

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Detalles Bibliográficos
Autores principales: Maciuba, Stephanie, Bowden, Gregory D., Stratton, Harrison J., Wisniewski, Kazimierz, Schteingart, Claudio D., Almagro, Juan C., Valadon, Philippe, Lowitz, Joshua, Glaser, Scott M., Lee, Grace, Dolatyari, Mahdi, Navratilova, Edita, Porreca, Frank, Rivière, Pierre J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498814/
https://www.ncbi.nlm.nih.gov/pubmed/37698877
http://dx.doi.org/10.1080/19420862.2023.2254676

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