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Brain PET and SPECT imaging and quantification: a survey of the current status in the UK

OBJECTIVES: With disease-modifying therapies in development for neurological disorders, quantitative brain imaging techniques become increasingly relevant for objective early diagnosis and assessment of response to treatment. The aim of this study was to evaluate the use of Brain SPECT and PET scans...

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Autores principales: Michopoulou, Sofia K., Dickson, John C., Gardner, Glen G., Gee, Thomas R., Fenwick, Andrew J., Melhuish, Timothy, Monaghan, Clare A., O’Brien, Neil, Prosser, Angus M.J., Scott, Catherine J., Staff, Roger T., Taylor, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498883/
https://www.ncbi.nlm.nih.gov/pubmed/37464866
http://dx.doi.org/10.1097/MNM.0000000000001736
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author Michopoulou, Sofia K.
Dickson, John C.
Gardner, Glen G.
Gee, Thomas R.
Fenwick, Andrew J.
Melhuish, Timothy
Monaghan, Clare A.
O’Brien, Neil
Prosser, Angus M.J.
Scott, Catherine J.
Staff, Roger T.
Taylor, Jonathan
author_facet Michopoulou, Sofia K.
Dickson, John C.
Gardner, Glen G.
Gee, Thomas R.
Fenwick, Andrew J.
Melhuish, Timothy
Monaghan, Clare A.
O’Brien, Neil
Prosser, Angus M.J.
Scott, Catherine J.
Staff, Roger T.
Taylor, Jonathan
author_sort Michopoulou, Sofia K.
collection PubMed
description OBJECTIVES: With disease-modifying therapies in development for neurological disorders, quantitative brain imaging techniques become increasingly relevant for objective early diagnosis and assessment of response to treatment. The aim of this study was to evaluate the use of Brain SPECT and PET scans in the UK and explore drivers and barriers to using quantitative analysis through an online survey. METHODS: A web-based survey with 27 questions was used to capture a snapshot of brain imaging in the UK. The survey included multiple-choice questions assessing the availability and use of quantification for DaTscan, Perfusion SPECT, FDG PET and Amyloid PET. The survey results were reviewed and interpreted by a panel of imaging experts. RESULTS: Forty-six unique responses were collected and analysed, with 84% of responses from brain imaging sites. Within these sites, 88% perform DaTscan, 50% Perfusion SPECT, 48% FDG PET, and 33% Amyloid PET, while a few sites use other PET tracers. Quantitative Brain analysis is used in 86% of sites performing DaTscans, 40% for Perfusion SPECT, 63% for FDG PET and 42% for Amyloid PET. Commercial tools are used more frequently than in-house software. CONCLUSION: The survey showed variations across the UK, with high availability of DaTscan imaging and quantification and lower availability of other SPECT and PET scans. The main drivers for quantification were improved reporting confidence and diagnostic accuracy, while the main barriers were a perception of a need for an appropriate database of healthy controls and a lack of training, time, and software availability.
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spelling pubmed-104988832023-09-14 Brain PET and SPECT imaging and quantification: a survey of the current status in the UK Michopoulou, Sofia K. Dickson, John C. Gardner, Glen G. Gee, Thomas R. Fenwick, Andrew J. Melhuish, Timothy Monaghan, Clare A. O’Brien, Neil Prosser, Angus M.J. Scott, Catherine J. Staff, Roger T. Taylor, Jonathan Nucl Med Commun Original Articles OBJECTIVES: With disease-modifying therapies in development for neurological disorders, quantitative brain imaging techniques become increasingly relevant for objective early diagnosis and assessment of response to treatment. The aim of this study was to evaluate the use of Brain SPECT and PET scans in the UK and explore drivers and barriers to using quantitative analysis through an online survey. METHODS: A web-based survey with 27 questions was used to capture a snapshot of brain imaging in the UK. The survey included multiple-choice questions assessing the availability and use of quantification for DaTscan, Perfusion SPECT, FDG PET and Amyloid PET. The survey results were reviewed and interpreted by a panel of imaging experts. RESULTS: Forty-six unique responses were collected and analysed, with 84% of responses from brain imaging sites. Within these sites, 88% perform DaTscan, 50% Perfusion SPECT, 48% FDG PET, and 33% Amyloid PET, while a few sites use other PET tracers. Quantitative Brain analysis is used in 86% of sites performing DaTscans, 40% for Perfusion SPECT, 63% for FDG PET and 42% for Amyloid PET. Commercial tools are used more frequently than in-house software. CONCLUSION: The survey showed variations across the UK, with high availability of DaTscan imaging and quantification and lower availability of other SPECT and PET scans. The main drivers for quantification were improved reporting confidence and diagnostic accuracy, while the main barriers were a perception of a need for an appropriate database of healthy controls and a lack of training, time, and software availability. Lippincott Williams & Wilkins 2023-10 2023-07-18 /pmc/articles/PMC10498883/ /pubmed/37464866 http://dx.doi.org/10.1097/MNM.0000000000001736 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Michopoulou, Sofia K.
Dickson, John C.
Gardner, Glen G.
Gee, Thomas R.
Fenwick, Andrew J.
Melhuish, Timothy
Monaghan, Clare A.
O’Brien, Neil
Prosser, Angus M.J.
Scott, Catherine J.
Staff, Roger T.
Taylor, Jonathan
Brain PET and SPECT imaging and quantification: a survey of the current status in the UK
title Brain PET and SPECT imaging and quantification: a survey of the current status in the UK
title_full Brain PET and SPECT imaging and quantification: a survey of the current status in the UK
title_fullStr Brain PET and SPECT imaging and quantification: a survey of the current status in the UK
title_full_unstemmed Brain PET and SPECT imaging and quantification: a survey of the current status in the UK
title_short Brain PET and SPECT imaging and quantification: a survey of the current status in the UK
title_sort brain pet and spect imaging and quantification: a survey of the current status in the uk
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498883/
https://www.ncbi.nlm.nih.gov/pubmed/37464866
http://dx.doi.org/10.1097/MNM.0000000000001736
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