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Tackling the lack of diversity in cancer research

Despite the clear benefit of studying biological samples from diverse genetic backgrounds and geographical locations, our current knowledge of disease is mostly derived from the study of European-descent individuals. In the cancer field, this is reflected in the poor representation of African and Am...

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Autores principales: Molina-Aguilar, Christian, Robles-Espinoza, C. Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499025/
https://www.ncbi.nlm.nih.gov/pubmed/37681401
http://dx.doi.org/10.1242/dmm.050275
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author Molina-Aguilar, Christian
Robles-Espinoza, C. Daniela
author_facet Molina-Aguilar, Christian
Robles-Espinoza, C. Daniela
author_sort Molina-Aguilar, Christian
collection PubMed
description Despite the clear benefit of studying biological samples from diverse genetic backgrounds and geographical locations, our current knowledge of disease is mostly derived from the study of European-descent individuals. In the cancer field, this is reflected in the poor representation of African and Amerindian/Latino samples in most large public data repositories. This lack of diversity is due to several reasons, but here we focus on (1) the lack of support for studies on non-European populations that are performed in low- and middle-income countries (LMICs), and (2) unequal partnerships between scientists in LMICs and those in high-income countries. We argue that expanding access to research funding, increasing the participation of underrepresented scientists in editorial boards and international conferences, facilitating the publication of studies conducted in these countries, and properly acknowledging LMIC researchers' contributions in publications and grant applications will promote equity for scientists working in LMICs. We envisage that this will translate to more impactful research in these countries, which will include more samples from diverse populations. For the cancer field, this will broaden our understanding of pathomechanisms and may help to improve the treatment of patients from all backgrounds.
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spelling pubmed-104990252023-09-14 Tackling the lack of diversity in cancer research Molina-Aguilar, Christian Robles-Espinoza, C. Daniela Dis Model Mech Perspective Despite the clear benefit of studying biological samples from diverse genetic backgrounds and geographical locations, our current knowledge of disease is mostly derived from the study of European-descent individuals. In the cancer field, this is reflected in the poor representation of African and Amerindian/Latino samples in most large public data repositories. This lack of diversity is due to several reasons, but here we focus on (1) the lack of support for studies on non-European populations that are performed in low- and middle-income countries (LMICs), and (2) unequal partnerships between scientists in LMICs and those in high-income countries. We argue that expanding access to research funding, increasing the participation of underrepresented scientists in editorial boards and international conferences, facilitating the publication of studies conducted in these countries, and properly acknowledging LMIC researchers' contributions in publications and grant applications will promote equity for scientists working in LMICs. We envisage that this will translate to more impactful research in these countries, which will include more samples from diverse populations. For the cancer field, this will broaden our understanding of pathomechanisms and may help to improve the treatment of patients from all backgrounds. The Company of Biologists Ltd 2023-09-08 /pmc/articles/PMC10499025/ /pubmed/37681401 http://dx.doi.org/10.1242/dmm.050275 Text en © 2023. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Perspective
Molina-Aguilar, Christian
Robles-Espinoza, C. Daniela
Tackling the lack of diversity in cancer research
title Tackling the lack of diversity in cancer research
title_full Tackling the lack of diversity in cancer research
title_fullStr Tackling the lack of diversity in cancer research
title_full_unstemmed Tackling the lack of diversity in cancer research
title_short Tackling the lack of diversity in cancer research
title_sort tackling the lack of diversity in cancer research
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499025/
https://www.ncbi.nlm.nih.gov/pubmed/37681401
http://dx.doi.org/10.1242/dmm.050275
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